No abstract

Gastric injury is mainly described by inflammation of the gastric epithelium. Recently, our group of work demonstrated that Prosthechea karwinskii leaves extract induces both an in vitro antioxidative action, and in vivo gastroprotective effect in the rat. However, the molecules involved in the gastroprotective action by Prosthechea karwinskii are not known. Thus, the aim of this study was to determine whether Prosthechea karwinskii extract modifies anti-inflammatory and antioxidative biomarkers in an in vivo rat model of indomethacin-induced gastric injury. Rats were orally administered with indomethacin and Prosthechea karwinskii leaves extract. Our results suggest that the gastroprotective effect of Prosthechea karwinskii leaves extract is related to the Embelin Benzoquinone 11.5 293.1787 C17H26O4