Spirocyclic Ag 9 clusters, as a new form of intrinsically chiral metal clusters, were constructed through vertexsharing of two in-situ-generated heteroaryl diide-centered metal rings. Such core-peripheral type clusters exhibit versatile photoluminescent and chiroptical behavior under different aggregation conditions. In contrast to a ligand-based fluorescence emission in a diluted solution of the clusters, a solvent polarity-caused assembly gives rise to new cluster-based phosphorous luminescence owing to radiative mode switching and aggregation-induced emission. Assembly of cluster enantiomers leads to micrometer-long helical nanofibers, whose handedness is determined by absolute configuration of individual spirocyclic clusters. Benefiting from exciton couplings of helical arrangements of chelating ligands at molecular and microscopic levels, the assembled film of cluster enantiomers exhibits circularly polarized luminescence with a high anisotropy factor (0.16).Scheme 1. Synthesis of spirocyclic clusters 1 and 2-(S).

Host‐targeting antivirals (HTAs) have received increasing attention for their potential as broad‐spectrum antivirals that pose relatively low risk of developing drug resistance. The repurposing of pharmaceutical drugs for use as antivirals is emerging as a cost‐ and time‐ efficient approach to developing HTAs for the treatment of a variety of viral infections. In this study, we used a virus titer method to screen 30 small molecules for antiviral activity against Herpes simplex virus‐1 (HSV‐1). We found that the small molecule RAF265, an anticancer drug that has been shown to be a potent inhibitor of B‐RAF V600E, reduced viral loads of HSV‐1 by 4 orders of magnitude in Vero cells and reduced virus proliferation in vivo. RAF265 mediated cytoskeleton rearrangement and targeted the host cell's translation machinery, which suggests that the antiviral activity of RAF265 may be attributed to a dual inhibition strategy. This study offers a starting point for further advances toward clinical development of antivirals against HSV‐1.

As part of Tarim platform, Kepingtage area lies between southwest Tienshan and Tarim basin, and its tectonic‐uplift evolution is closely correlated with Tienshan and Tarim basin. The (U‐Th)/He thermochronometry is used as a new technique to study the tectonic uplift of Kepingtage area in the paper. Based on the measured apatite/zircon (U‐Th)/He ages of Sinian outcrop samples in the region and the thermal modeling, the results reveal four phases of tectonic‐uplift events appeared in Kepingtage area, which made the Sinian formation rise to the surface. The apatite (U‐Th)/He ages reveal two phases of uplift events at Late Cretaceous and Miocene. During Early Carboniferous, the Sinian formation temperature reached a maximum of 133~150°C. Combined with the burial history of the sample, the maximum depth can be derived to be 3400~3900m. Due to the distant effect from the collision of the Indian and Eurasian plates, Kepingtage area thrust over Bachu uplift along Kepingtage‐Shajingzi fault during the Oligocene‐Miocene. The strata were rapidly uplifted and eroded. During 15~10Ma, the Sinian formation in Kepingtage area had been uplifted to the surface. The total exhumation amount is up to 6170m since Early Carboniferous. While the tectono‐thermal evolution history of the Kepingtage area is consistent with the northern margin of Tarim basin in Mesozoic to Cenozoic, it is inconsistent with Tienshan and the Bachu uplift inside Tarim basin. Since Miocene, Kepingtage area and Tienshan was in the same state of uplifting by the distant effect of the Himalayan movement; During Early Eocene, Bachu uplift area was still uplifted and eroded, while Kepingtage area received deposits. This paper successfully reveals the tectono‐thermal evolution history of Kepingtage area since Sinian using the (U‐Th)/He thermochronometry, which is useful for understanding the tectonic uplift in the region correctly. Furthermore, the study can support the hydrocarbon exploration of Tarim basin and the tectonic study of Tarim basin and Tienshan.

C(sp 2 )-centered homo-and hetero-nuclear gold complexes have attracted widespread interests in recent decades. Studies of this type of complexes may deepen the understandings of the intermediates in Au-catalyzed organic reactions and explore new applications in catalytic and material science. The focuses of this review include the synthesis, structural characteristics, properties and applications of C(sp 2 )-centered homo-and hetero-nuclear gold complexes according to different structural classifications. . His current research focuses on the controllable synthesis and reactivity studies of polynuclear organometallic clusters and supramolecular self-assembly of metal clusters.