We reviewed scientific literature on the problem of osteosynthesis of long tubular human bones, published during the last 10 years. The Scopus, Web of Scince, Pubmed, RSCI databases were searched for the articles reporting the results of clinical studies and biomechanical experiments using plate osteosynthesis. The advantages and disadvantages of minimally invasive plate osteosynthesis for different segments have been revealed. The articles reported a lower probability of displacement development in minimally invasive plate osteosynthesis in comparison with intramedullary osteosynthesis, good biological conditions for fracture healing, decreased rate of complications of postoperative wounds due to reduced incisions. In the concept of biological osteosynthesis, the advantage of axial dynamization and fracture micro-mobility over absolute rigidity was noted. The study also revealed the influence of the parameters of a plate and osteosynthesis technique on the rigidity of the plate-bone system, such as: the working length of the plate, the number of screws on the plate, types of screws (cortical or locking), the plate material and its profile. The bone osteosynthesis seemed to have new directions of evolution. These include far cortical locking screws allowing micromobility under the plate, providing a "controlled dynamization". An experimental technology of Active Locking Plates has been reported, where the screws with angular stability are locked in holes on elastic sliding elements providing micromobility of the screw relative to the plate. In general, all the visible results differed in various studies and, sometimes, contradicted each other.

Three-dimensional printing opens up many opportunities for use in traumatology and orthopedics, because it takes into account personal characteristics of the patients. Modern methods of high-resolution medical imaging can process data to create threedimensional images for printing physical objects. Today, three-dimensional printers are able to create a model of any complexity of shape and geometry. The article provides a review of the literature about three-dimensional digital modeling in shaping implants for osteosynthesis. Data search was carried out on the Scopus, Web of Scince, Pubmed, RSCI databases for the period 2012–2022. The effectiveness of three-dimensional printing for preoperative modeling of bone plates has been confirmed: implants perfectly corresponds with the unique anatomy of the patient, since the template for it is based on the materials of computed tomography. Individual templates can be useful when the geometry of patients' bones goes beyond the standard, and when improved results of surgery are expected due to better matching of implants to the anatomical needs of patients.

Aim - to improve the results of treatment of patients with complex regional pain syndrome (CRPS) in bone fractures of the lower extremities by applying a new integrated approach. Methods. A new approach to solving the problem of complex regional pain syndrome in fractures of lower limb bones is proposed, including the use of modern minimally invasive methods for surgical treatment of fractures of the lower limb bones, such as blocked osteosynthesis, Fixion technology, use of angular stability plates, metal structures for osteosynthesis of the proximal femur. All these measures help to minimize the negative effect that is produced on the bone by such factors as prolonged immobilization and absence of early movements of the joints, which will make it possible to perform CRPS prophylaxis in bone fractures of the lower limbs more effectively. If it is not possible to prevent the development of CRPS, then it is necessary to administer complex therapy, including psychoemotional correction, adherence to the regime, proper immobilization, rehabilitation exercises, physiotherapy, medical treatment, hyperbaric oxygenation, and gravitational therapy. Results. Clinical tests, radiography, densitometry, method of statistical analysis and mathematical modeling with elements of evidencebased medicine objectively confirmed the activation of the restorative processes in altered tissues of the lower limbs due to the use of the new complex. Conclusion. The analysis of the obtained data of clinical and functional methods of research has proved that the total value of positive results is 80%.

Aim to evaluate the effectiveness of restoring the lateral ankle ligament complex using local tissues according to the Brostrom Gould technique in patients with different post-traumatic periods. Material and methods. In 2021, in total 15 patients with lateral ankle instability underwent clinical and instrumental examination and received surgical treatment for this pathology. The patients were divided into three groups depending on the time passed from the primary injury. Group 1 included patients with a post-traumatic period up to 5 years, Group 2 up to 10 years and Group 3 more than 10 years. The ankle instability was assessed before and after surgery using the AOFAS and Karlsson Peterson scales. Results. In Groups 1 and 2, the patients were satisfied with the results of treatment They could restore the intensity of their physical activity to the level they had before the injury. The patients from Group 3 were not content with the results of treatment and reported the remaining pain, swelling, and joint instability. Conclusion. With a disease duration of up to 5 years, Brostrom Gould procedure provides excellent results and remains the preferred treatment for lateral ankle instability. This technique can be successfully used in patients with the post-injury period up to 10 years, if their life-style does not imply the regular intensive load on the ankle. If the history of the disease is more than 10 years, the Brostrom Gould procedure is ineffective, in such cases other complex treatment methods should be used.