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Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage. In view of the considerable side effects produced by the available analgesics, the search for a newer analgesic continues. The aim of this study is to anti nociceptive effects of various neuroleptics in animal models of pain have been described. The aim of our present study is to evaluate the analgesic activity of Amisulpride, an atypical antipsychotic in comparison with Tramadol, which is a synthetic opioid analgesic. The analgesic effect of Amisulpride was evaluated using Eddy's hot plate. The drugs were administered sub-cutaneously. In this test the reaction times i.e., the latency periods in the animals were recorded in all the three groups (control, standard and test groups) at 30 min, 60 min and 90 min time interval after drug administration. Each group contains 6 animals. The increase in reaction time in response to a drug denotes analgesic effect of the drug. The reaction times in the test group were compared with standard and control. Results were analyzed by ANOVA followed by post hoc Dunnett's test. According to Dunnett's test, the p value was very significant in Control vs test group at 90 min, which implies that Amisulpride (44 mg/kg) has significant analgesic effect at 90 min time interval after drug administration. P values were very significant at 30 min and 60 min and not significant at 90 min in Standard group versus Test group, which implies that the test drug (Amisulpride) has analgesic effect comparable to that of standard drug (Tramadol) at 90 min. This study suggests that Amisulpride has significant analgesic effect at 90 min. The analgesic effect of Amisulpride (44 mg/kg) is comparable to that of standard drug Tramadol (20 mg/kg) at 90 min.