SummaryBmkgroimd: The genetic factors that contribute to ischemic heart disease (IHD) are poorly understood, and it is likely that multiple genes acting independently or synergistically contribute to the risk of IHD and outcome. The genes for angiotensin-converting enzyme (ACE) and apolipoprotein E (ApoE) have been implicated independently in the risk oflHD.Hypothesis: This study examined whether genetic polymorphisms in the ACE and ApoE genes are associated with early onset 1HD. Polymorphisms in a third gene, transforming growth factor p2 (TGF p2). with a known role in wound repair and cardiac development, are also examined with respect to early onset ED.Methods: In all, 101 patients with IHD and onset ofdisease before 55 years for men and 60 years for women, and 100 controls with angiographically confirmed normal coronary arteries were recruited for this study. The ACE, ApoE, and TGF p2 genotypes were determined by polymerase chain reaction amplification or Southern blotting and were compared with the patient's clinical and family histories.

No abstract

No abstract

No abstract