MAL PDT is an attractive option for 'difficult-to-treat' BCC. Because of the excellent cosmetic results, the treatment is particularly well suited for lesions that would otherwise require extensive surgical procedures.

Actinic keratoses need to be removed before they turn into SCCs. The prognostic significance of ulceration of cutaneous SCCs needs to be determined.

Background: The frequency with which squamous cell carcinoma (SCC) of the skin metastasizes is a matter of dispute. Studies from private practices have reported much lower rates than hospital-based surveys, and one school of thought is that SCCs which arise in sun-damaged skin have a low risk of metastasis. Methods: A prospective study of out-patients with histologically confirmed SCC was undertaken in southern Australia, a region with a very high incidence of skin cancer. Results: Between November 1988 and November 1989, 481 patients were entered into the study and 420 followed for at least 3 years. An SCC was the initial diagnosis for 73 patients, 3 were immunosuppressed and 2 had an SCC of the lip, leaving 68 immunocompetent patients with SCC of the skin. Metastatic SCC developed in 2 patients (5.8% adjusted for losses) within 3 years. The SCCs were small and arose in sun-damaged skin. Conclusion: Patients with SCC of the skin need a careful follow-up because of the risk of metastasis.

Ultrastructural examination of sweat glands from the human loin before and during heat-induced activity indicated that the sweat is formed from the contents of disrupted cells as well as from the products of secretion. The principal secretory processes appear to be fluid transport and exocytosis of vesicles. However, configurations suggesting microapocrine secretion were also observed. It is concluded that the mechanisms involved in sweat production in man are fundamentally similar to those in animals and the terms 'apocrine' and 'eccrine' should be discarded. The myoepithelial cells which were contracted at the onset of sweating appeared to be under less tension after 3 h of continuous activity.