Actinic keratoses need to be removed before they turn into SCCs. The prognostic significance of ulceration of cutaneous SCCs needs to be determined.

No abstract

However, Brewster and colleagues found a left-sided excess of melanoma exists even in countries where vehicles are driven from the right side, such as the United Kingdom and Australia. As this is inconsistent with driving-related exposure, it was theorised that this left-sided predominance may be due to anatomical or embryological asymmetry, or some unknown other difference in ultraviolet exposure. 6,7 Our study found that there was no significant laterality in the distribution of malignant and premalignant skin lesions, regardless of age, gender, site of lesion or histopathological diagnosis.Driving-related ultraviolet exposure appears to no longer be a major factor in the distribution of melanoma and nonmelanoma skin cancer. This may be due to the increasing use of air conditioning in vehicles, or to attribution error in previous research. It is possible that a larger study, including clinical components such as field UV damage and skin type and detailed demographic data such as occupation and patterns of sun exposure, may be able to further characterise any small difference in laterality of these skin lesions.

Actinic keratoses need to be removed before they turn into SCCs. The prognostic significance of ulceration of cutaneous SCCs needs to be determined.

No abstract