Background The relationship between autoimmune thyroid disease and systemic lupus erythematosus (SLE) has been revealed but the prevalence of thyroid disease in lupus patients is controversial. Objectives The aim of this study is to assess thyroid dysfunction and the presence of anti-thyroid antibodies in patients with SLE, and its association with disease characteristics and disease activity. Methods Sixty patients with SLE ≥18 years who satisfied the American College of Rheumatology (ACR) criteria and thirty age and sex matched normal volunteers were included, all underwent laboratory evaluation for serum free T3, free T4, TSH, Antithyroglobulin antibody (Ab TG) and Antithyroid peroxidase antibody (Ab TPO). Clinical and serological characteristics and disease activity of SLE were assessed; correlation with thyroid dysfunction was studied. Results 2 patients (3.33%) had subclinical hyperthyroidism, 24 patients (40%) were euthyroid, 12 patients (21.67%) had subclinical hypothyroidism and 22 patients (35%) had overt hypothyroidism. All subjects of the control group were euthyroid. Patients with thyroid dysfunction had more arthralgias, arthritis, changes of voice, bowel habits and weight, irregular menstruation, sleep disturbance, nervousness and tremors than the euthyroid lupus patients (p<0.05). The lupus patients with subclinical and overt hypothyroidism had statistically significant higher (Ab TG) than the euthyroid patients and patients with subclinical hyperthyroidism and control group (p<0.05) but no statistically significant difference between all groups as regard (Ab TPO). SLE patients with subclinical and overt hypothyroidism had statistically significant higher ESR and SLAM score than the euthyroid patients and patients with subclinical hyperthyroidism (p<0.05). There was a positive correlation between (Ab TG) levels and body mass index BMI, ESR and disease activity measures by SLAM score (p<0.05). Conclusions The thyroid dysfunction is more frequent in SLE patients than control group. Subclinical and overt hypothyroidism are more likely to occur in SLE patients. There are a positive correlation between (Ab TG) levels and disease activity and negative correlation with free T3 & free T4. References Zakeri Z. & Sandooghi M. Thyroid Disorder in Systemic Lupus Erythematosus Patients in Southeast Iran. Shiraz E Medical Journal.2010; 11: 34-8. Scofield RH. Autoimmune thyroid disease in systemic lupus erythematosus and Sjögren's syndrome. Clin Exp Rheumatol 1996; 14: 321-30. Boey ML., Fong PH., Lee JSC., Ng WY. & Thai AC. Autoimmune thyroid disease in SLE in Singapore. Lupus 1993; 2: 51-4. Magaro M., Zoli A., Altomonte L., Mirone L., La Sala L., Barini A. & Scuderi F. The association of silent thyroiditis with active systemic lupus erythematosus. Clin Exp Rheumatol.1992;10:67. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.1623

Background Behçet’s disease (BD) is also referred to as vascular BD when it frequently involves the heart and vessels. This study aimed to describe the cardiovascular manifestations in patients with BD and its correlation to disease activity. We conducted a cross-sectional study on 40 patients diagnosed with BD according to the International Criteria for Behçet’s Disease 2014. All the patients were subjected to detailed history taking, full clinical examination, lab investigations, resting electrocardiogram, trans-thoracic echocardiography, and carotid artery duplex for measuring intimal thickness, peripheral arterial and venous duplex, computed tomography pulmonary angiography, and full ophthalmological examination. Regarding the activity of the disease, it was assessed according to the score of Behçet’s Disease Current Activity Form (BDCAF). Results The most common cardiac manifestation was valvular lesion (67.5%) where the most frequently affected valve was the tricuspid valve (27.5%). Although 25% of patients had left ventricular diastolic dysfunction, only 5% had intracardiac masses. Approximately 52.5% of patients had vascular lesion (deep venous thrombosis 45%, arterial involvement 7.5% [as pulmonary artery thrombosis 5% and aneurysm 2.5%]). Increase in intima media thickness (IMT) was observed in 7.5% of patients, while 60% had abnormal lipid profiles. Hypercholesterolemia was the most common lipid abnormality (50%). BDCAF score range was 4–12, which was significantly correlated to multiple cardiovascular parameters as a mitral, tricuspid valve, and vascular venous involvement (p < 0.05), while not significantly correlated to lipid profile (p > 0.05). Conclusion Cardiovascular complications are frequent among patients with BD, even those who are asymptomatic; therefore, these complications must be screened for early detection and proper management.

Background: The relationship between autoimmune thyroid disease and systemic lupus erythematosus (SLE) has been revealed but the prevalence of thyroid disease in lupus patients is controversial. The aim of this study is to assess thyroid dysfunction and the presence of anti-thyroid antibodies in patients with SLE, and its association with disease characteristics and disease activity. Methods: Sixty patients with SLE ≥ 18 years who satisfied the American College of Rheumatology (ACR) criteria and thirty age and sex matched normal volunteer were included, all underwent laboratory evaluation for serum free T3, free T4, TSH, Antithyroglobulin antibody (Ab TG) and Antithyroid peroxidase antibody (Ab TPO). Clinical and serological characteristics and disease activity of SLE were assessed; correlation with thyroid dysfunction was studied. Results: 2(3.33%) patients had subclinical hyperthyroidism, 24 (40%) were euthyroid, 12 (21.67%) had subclinical hypothyroidism and 22 (35%) had overt hypothyroidism. All the control group was euthyroid. The patients with thyroid dysfunction had more arthralgias, arthritis, changes of voice, bowel habits and weight, irregular menstruation, sleep disturbance, nervousness and tremors than the euthyroid lupus patients (p<0.05). The lupus patients with subclinical and overt hypothyroidism had statistically significant higher Ab TG than the euthyroid patients and patients with subclinical hyperthyroidism and control group (p<0.05) but no statistically significant difference between all groups as regard Ab TPO. SLE patients with subclinical & overt hypothyroidism had statistically significant higher ESR and SLAM score than the euthyroid patients and patients with subclinical hyperthyroidism (p<0.05). There was a positive correlation between Ab TG levels and body mass index BMI, ESR and disease activity measures by SLAM score (p<0.05). Conclusion: The thyroid dysfunction is more frequent in SLE patients than control group. Subclinical and overt hypothyroidism are more likely to occur in SLE patients. There are a positive correlation between Ab TG level and disease activity and negative correlation with free T3 & free T4.

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Background Behcet’s disease is an auto immune disease with multisystem affection, the most common manifestations are in the form of oral or genital ulcers, eye affection, recurrent thrombosis . Behcet’s disease is a chronic disease with many sequelae, sometimes fatal, the treatment is by immunosuppressive therapy which also had its implications on the long term, unfortunately it has no sure diagnostic tests and relies mainly on clinical criteria, there are few scores to assess behcet’s disease activity (Behcet's Disease Current Activity Form) BDCAF score is a reliable follow up tool with wide accreditation. BD can virtually involve any organ system, cardiac involvement is variable and sought to occur in the range of 7-46% of patients and may cause myocardial infarction, pericarditis, valve problems, aneurysms or congestive heart failure. Different types of vessels, predominantly veins, can be affected in BD. The frequency of vascular lesions in BD, such as superficial and deep venous thromboses, arterial aneurysms and occlusions, ranges between 7-29%. Aims To assess cardiovascular manifestations for patient diagnosed as Behçet disease (BD) and its correlation to disease activity. Methods This was a cross sectional study which was done on 40 Behcet’s disease patients within the year 2019, it was done for the assessment of cardiovascular manifestations for patient diagnosed as Behçet disease (BD) and its correlation with BDCAF score (Behcet’s disease current activity form). The study group was subjected to full history, clinical examination including activity which was assessed according to BDCAF score (BEHCET'S DISEASE CURRENT ACTIVITY FORM), Assessment of any activity regarding the eyes using fundus examination, routine laboratory investigations including Complete blood count (CBC), Erythrocyte sedimentation rate (ESR), Creactive protein (CRP), lipid profile, liver enzymes. Results it was found that there is a positive correlation between BDCAF (behcet's disease current activity form) and cardiovascular affection (especially valvular lesions and vascular venous affection).