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The results obtained by us (1948a) with maleic acid as an inhibitor of mitosis have been developed in an attempt to prepare other mitotic inhibitors related to maleic acid; in particular we have investigated the antimitotic activity of substances in which the maleic acid residue is part of an aliphatic ring. The imides of maleic acid (I) and of citraconic acid (II), N-ethylmaleimide (III), -and in addition succinimide (IV) were chosen for this purpose.

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The products, which are additive in molecular formula, are shown t o be thiocarbanilide. probably thiazolidones of type (111).To further the investigation of the reactivity of maleimides towards free thiol groups (Friedmann, Marrian, and Simon-Reuss, Brit. J . PharmacoZ., 1949, 4, 105; Marrian, this vol., p. 1515) * Bougault and Chabrier (Compt. re?zd., 1947, 224, 656) have shown that benzoylacrylic acid and thiourea react analogously.

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