One hundred and ninety women who contracted toxoplasmosis after the seventh week of pregnancy underwent antenatal diagnosis, including ultrasound examination and biological tests. Tests included Toxoplasma isolation in fetal blood and amniotic fluid by mouse inoculation, specific IgM and IgA in fetal blood, and non-specific tests. Twenty fetuses had positive specific as well as non-specific tests for Toxoplasma infection. At birth, four of these presented with clinical congenital toxoplasmosis and 12 with subclinical forms. Antenatal diagnosis enabled the detection of 83 per cent of the infected fetuses. Under specific conditions, cordocentesis permits early diagnosis and considerably reduces the number of terminations of pregnancy.

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Pour la première fois deux souches de Leishmanies, isolées en Cévennes d'une popula tion naturelle de Phlebotomus ariasi, sont identifiées par la méthode enzymatique. Elles se rap portent toutes deux au zymodème 1, caractéristique de Leishmania infantum s. st. Ecology of leishmaniasis in the south of France. 18. Enzymatic identification of Leishmania infantum Nicolle, 1908, isolated from Phlebotomus ariasi Ton noir, 1921, spontaneously infected in the Cévennes. SUMMARY. Out of 187 female Phlebotomus ariasi caught in the Cévennes focus of leishmaniasis 3 were found naturally infected with Leishmania. The infection in one of the three had spread from the midgut to the pharynx and proboscis. Stocks of Leishmania were isolated from two of the flies and 8 isoenzymes were examined. The newly isolated parasites were found to be in distinguishable from zymodeme 1 of Leishmania infantum s. st.

Leishmania major, agent of zoonotic cutaneous leishmaniasis, has been isolated from the rodent Meriones shawi shawi in central Tunisia. As a result, the North saharan arid mediterranean area can be considered as epidemiologically homogeneous.