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SummaryPropofol was given by continuous intravenous infusion to 10 patients with severe head injuries in the intensive care unit. Heart rate, mean arterial blood pressure, intracranial pressure, cerebral perfusion pressure, pupil size and arterial carbon dioxide tension were recorded throughout the study period. A mean infusion rate of 2.88 mglkglhour provided satisfactory sedation, and recovery from the propofol was often rapid. Cerebraf perfusion pressure was signijicantly increased at 24 hours.

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