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1 Nadolol excretion was studied in 24 patients with chronic renal failure. 2 The amount of nadolol excreted during the 120‐h period after receiving the drug ranged from less than 1% in functionally anephric, patients up to 11.5% in patients with average creatinine clearance of 57.9 +/‐ 3.6 ml/min/1.73 m2. 3 Renal clearance of nadolol was found to correlate with creatinine clearance; nadolol elimination is retarded in patients with renal failure. 4 Nadolol serum half‐life is prolonged in proportion to the remaining renal function. Therefore, dosage intervals in renal patients receiving nadolol should be adjusted to creatinine clearance. 5 Haemodialysis effectively reduced serum concentration of the drug; it may therefore be a useful therapy for drug intoxication.

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thiamine pyrophosphatase a c t i v i t y was l o c a l i z e d w i t h i n t h e innermost l a m e l l a e o f t h e Golgi complex and, t o a l e s s e r e x t e n t , w i t h i n c i s t e r n a e o f t h e rough endoplasmic r e t i c u l u m . In axons, thiamine pyrophosphatase a c t i v i t y was l o c a l i z e d w i t h i n t u b u l a r p r o f i l e s , presumed t o be endoplasmic r e t i c u l u m , and i n axonal t e r m i n a l s i t was found w i t h i n presynaptic v e s i c l e s . a c t i v i t y suggests t h e d e r i v a t i o n o f synaptic v e s i c l e s from membranes o f t h e Golgi complex.I n t h e p e r i k a r y a o f p o n t i n e r e t i c u l a r f o r m a t i o n neurons This s e l e c t i v e l o c a l i z a t i o n o f pyrophosphataseThe submicroscopic d i s t r i b u t i o n o f thiamine pyrophosphatase (TPPase) , t h e enzyme which c a t a l y z e s t h e r e l e a s e o f i n o r g a n i c phosphate from s u b s t r a t e thiamine pyrophosphate, i s demonstrated i n e l e c t r o n micrographs by a r e l i a b l e cytochemical procedure ( N o v i k o f f e t a1 . , '71 ; G o l d f i s c h e r e t a1 . , '71 ; A l l e n , ' 6 3 ) . p o s s i b l y coupled t o s u b s t r a t e i n t h e medium (Berg, '64), t o form a dense i n s o l u b l e r e a c t i o n product a t t h e i n t r a c y t o p l a s m i c s i t e s o f TPPase a c t i v i t y

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