With a fiber coupled laser diode array as the pump source, Nd-doped Lu 2 SiO 5 (Nd:LSO) crystal lasers at 4 F 3/2 → 4 I 11/2 and 4 F 3/2 → 4 I 13/2 transitions were demonstrated. The active Q-switched dual-wavelength lasers at about 1.08 µm, as well as continuous-wave (CW) and active Q-switched lasers at 1357 nm are reported for the first time, to the best of our knowledge. Considering the small emission cross-sections and long fluorescence lifetime, this material possesses large energy storage ability and excellent Q-switched properties. The special emission wavelength at 1357 nm will have promising applications to be used in many fields, such as THz generation, pumping of Cr 3+ :LiSAF, repumping of strontium optical clock, laser Doppler velocimeter and distributed fiber sensor.