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Hydrogels are hydrophilic polymers that swell to an equilibrium volume in the presence of water, preserving their shape. The dynamic swelling behavior of poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide) [poly(NIPA-co-DMA)] copolymers at 37°C was investigated. It was observed that the swelling degree in the copolymers decreases with the N-isopropylacrylamide content. In addition, the liberation mechanism was found to be Fickian. Diffusion coefficients according to FickЈs law as a function of the N-isopropylacrylamide concentration and results of the release process are reported. The kinetics of cephazoline sodium release from poly(NIPA-co-DMA) hydrogels with different compositions was studied.