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Introduction Myoepithelioma primarily affects the parotid gland and usually presents as a slow-growing painless lump. The aim of this paper is to report a case of myoepithelioma in the mouth floor. Case outline A young man noticed a painless increased volume in the left side of the mouth floor region, which after one year of evolution presented as a sessile tumor with normal colored mucosa and the absence of secretion output. Computed tomography with contrast showed an image with slightly heterogeneous density, with well-defined limits. Incisional biopsy was performed under local anesthesia, and pathology examination of the sample revealed a myoepithelial neoplasm. Total excision of the lesion was performed under general anesthesia, and histopathological examination confirmed the diagnosis of the salivary gland myoepithelioma. The patient did not present signs of relapse after a year of follow up. Conclusion Despite the fact that myoepithelioma originating in the salivary gland are considered rare, especially in the mouth floor, this tumor should be considered in the differential diagnosis of similar lesions. Proper treatment appears to be complete surgical excision and post-operative follow-ups shows should be carried out as long as possible, despite the fact that relapses are extremely rare.

Down syndrome is the foremost common genetic cause of intellectual disability. The additional copy of chromosome 21 confers potential changes in virtually all organ systems, including the brain, neck structures, and spine. Neuroradiologists should be aware of the multitude of imaging findings in patients with Down syndrome to correctly identify and diagnose life-altering conditions associated with this syndrome. In particular, the high prevalence of age-related cognitive decline and dementia stands out more clearly in recent decades due to the notable increase in these individuals' survival. Although the early and timely diagnosis of cognitive decline in patients with varying degrees of intellectual disability has not been an easy task from the clinical point of view, anatomic and functional brain studies have shown an essential role because they allow the early recognition of abnormalities that precede the cognitive decline. Furthermore, the similarities and differences in neuropathologic, genetic, and imaging aspects in patients with Down syndrome have allowed extrapolation for a better understanding of the mechanisms linked to Alzheimer disease development.Learning Objective: To review and systematize the distinctive characteristics and abnormalities of the head and neck, vertebral column, and CNS present in Down syndrome