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1 The ocular hypotensive effect of 0.025% bromocriptine and 0.25% timolol eye drops was compared in nine healthy human volunteers, using non-contact tonometry. 2 Considering all post-dosing measurements compared with placebo and including the baseline values as continuous independent variables, using multiple linear regression analysis, both bromocriptine and timolol had a significant ocular hypotensive effect (P < 0.0001) in the treated eye with a significant but lesser effect in the contralateral eye.3 In the concentrations used, timolol was more efficacious than bromocriptine in lowering intraocular pressure (P < 0.025). 4 Using other forms of vehicles for bromocriptine to improve efficacy and studying the ocular hypotensive effect of topical application of other dopamine-2-receptor agonists such as pergolide and lisuride was suggested.Keywords bromocriptine dopaminergic agonists intraocular pressure non-contact tonometer timolol