Drug effects on mouse exploratory behavior

Wakeley, H; O'sullivan, D. P. D.

doi:10.3758/bf03331896

Cited by 12 publications

(7 citation statements)

References 2 publications

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“…differentially affected visual exploratory behavior and spontaneous motor activity. These findings were consistent with previous reports (Kumar, 1969;Wakeley & O'Sullivan, 1969;Dyne & Hughes, 1970 phetamine in Kumar's study showed a reduction in trough exploration while they showed an increase in locomotor activity in a non-specific manner. Wakeley and O'Sullivan (1969) reported that d-amphetamine (1.0-10.0 mg/kg) decreased poke behavior in the hole (exploration) but increased locomotor activity in mice.…”

Section: Discussionsupporting

confidence: 93%

“…These findings were consistent with previous reports (Kumar, 1969;Wakeley & O'Sullivan, 1969;Dyne & Hughes, 1970 phetamine in Kumar's study showed a reduction in trough exploration while they showed an increase in locomotor activity in a non-specific manner. Wakeley and O'Sullivan (1969) reported that d-amphetamine (1.0-10.0 mg/kg) decreased poke behavior in the hole (exploration) but increased locomotor activity in mice. It was found that methylphenidate (a stimulant) also decreased the approach behavior to the novel environment (exploration) while increasing randomized general activity (Dyne & Hughes, 1970).…”

Section: Discussionsupporting

confidence: 93%

“…The assumption that the arousal level is reflected in spontaneous motor activity could not be fully demonstrated in the present experiments. The results of the above studies (Kumar, 1969;Wakeley & O'Sullivan, 1969;Dyne & Hughes, 1970) supported this assumption in rats and mice. The partial inconsistency between the present results and their ones may be attributed to the species difference.…”

Section: Discussionsupporting

confidence: 55%

“…In that report he employed entries into the arms of the maze as a measure of locomotor activity and investigation (sniffing) of the troughs at the end of arms as that of exploration. Wakeley and O'Sullivan (1969), using mice, reported that d-amphetamine and chlorpromazine (CPZ) decreased exploratory behavior (poke in the hole) whereas locomotor activity was differentially affected by the two drugs, i.e., d-amphetamine increased locomotor activity whereas CPZ decreased it. Methylphenidate (a stimulant) inhibited the behavior directed specifically towards the more novel components of an environment (exploration) and facilitated randomized general activities characterized by a lack of consistent environmental orientation (Dyne & Hughes, 1970).…”

Section: The Differential Effects Of Methamphetamine Upon Visual Explmentioning

confidence: 99%

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THE DIFFERENTIAL EFFECTS OF METHAMPHETAMINE UPON VISUAL EXPLORATORY BEHAVIOR AND SPONTANEOUS MOTOR ACTIVITY IN RHESUS MONKEYS (<I>Macaca mulatta</I>)

Ibuka

1971

Jpn. Psychol. Res

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The differential effects of methamphetamine (2 mg/kg, i.m.) upon visual exploratory behavior and spontaneous motor activity were studied with rhesus monkeys (Exp. I, n=10, Exp. II, n=6).The frequency and cumulative time of the approach response to the visual stimulus (either a flickering light or a peer monkey) were recorded as an index of visual exploratory behavior and spontaneous motor activity was also measured in terms of photobeam breaks by the S's spontaneous movements. It was found that methamphetamine significantly inhibited the approach response to the visual stimulus, but spontaneous motor activity obtained concurrently with visual exploratory behavior was elevated in some monkeys but depressed in other monkeys. The results were discussed in relation to Berlyne's arousal hypothesis.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 55%

Section: The Differential Effects Of Methamphetamine Upon Visual Explmentioning

confidence: 99%

See 2 more Smart Citations

THE DIFFERENTIAL EFFECTS OF METHAMPHETAMINE UPON VISUAL EXPLORATORY BEHAVIOR AND SPONTANEOUS MOTOR ACTIVITY IN RHESUS MONKEYS (<I>Macaca mulatta</I>)

Ibuka

1971

Jpn. Psychol. Res

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“…This theory was supported by experiments in which exploratory behavior failed to habituate in drugged rats and mice. In these experiments, the following measures were taken : (1) responsiveness to a novel chamber (measured by running time) following preexposure under the influence of an anticholinergic drug (Carlton & Vogel, 1965); (2) choice behavior in a novel T-maze while under the effects of an anticholinergic drug (Meyers & Domino, 1964 ;Douglas & Isaacson, 1966 ;Squire, 1969 ;Leaton, 1968Leaton, , 1969 ; (3) effects of an anticholinergic drug on light-reinforced barpressing (Carlton, 1966) and on the frequency of nose insertions (Wakeley & O'Sullivan, 1969). The results of these experiments support the hypothesis that anticholinergic drugs attenuate habituation to novelty.…”

mentioning

confidence: 99%

Effects of scopolamine on inhibitory mechanisms

Graf

1974

Psychobiology

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Scopolamine-injected rats remained withdrawn from a novel chamber longer than controls under free exploratory conditions (Ss could withdraw into the home cage). This finding was interpreted to mean that scopolamine prevented the habituation of fear induced by the novel chamber. Under forced exploratory conditions (Ss had no opportunity to withdraw), scopolamine-injected rats showed: (1) continuous general motor behavior rather than a within session decrease as found in control rats; (2) as much within session decrease in locomotion, scanning, and object contact as did controls. These results were interpreted to mean that scopolamine produced a disinhibitory effect on general motor activity without interfering with behavioral response habituation. It was further suggested that the drug's disinhibitory effect on fear and general motor activity is due to the impairment of an inhibitory cholinergic system within the brain, but that this same cholinergic system does not mediate the inhibitory process underlying behavioral response habituation.

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The reliability of the hole-board apparatus

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Wardill

1975

Psychopharmacologia

197

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Two aspects of the reliability of the hole-board apparatus were investigated-the similarity between scores of different samples of the same population on their first exposure to the apparatus, and the test-retest reliability. Rats and mice were given a 5-min exposure to the hole-board and then retested for 5 min after 1, 2 or 8 days. Male rats and mice showed good initial exposure reliability, whereas the female mouse groups differed significantly. All animals showed a positive test-retest correlation (range 0.31-0.78), but a homogeneous group (e.g. all animals habituating) produced higher correlations (range 0.60-0.99). Comparison of scores on the two 5-min exposures showed that not all groups showed significant habituation, but the animals exposed to the hole-board for two 10-min periods showed both significant habituation and test-retest reliability.

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Drug effects on mouse exploratory behavior

Cited by 12 publications

References 2 publications

THE DIFFERENTIAL EFFECTS OF METHAMPHETAMINE UPON VISUAL EXPLORATORY BEHAVIOR AND SPONTANEOUS MOTOR ACTIVITY IN RHESUS MONKEYS (<I>Macaca mulatta</I>)

THE DIFFERENTIAL EFFECTS OF METHAMPHETAMINE UPON VISUAL EXPLORATORY BEHAVIOR AND SPONTANEOUS MOTOR ACTIVITY IN RHESUS MONKEYS (<I>Macaca mulatta</I>)

Effects of scopolamine on inhibitory mechanisms

The reliability of the hole-board apparatus

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