Isoniazid (1) on reaction with 5-arylfuran-2-carboxaldehydes (2a-e) yield N'-((5-Arylfuran-2-yl) methylene) isonicotinohydrazide (3a-e). Post reaction of these hydrazones (3a-e) with mercapto acetic acid afforded N-(4-oxo-2-(5-Arylfuran-2-yl) thiazolidin-3-yl) isonicotinamide (4a-e). Such 4-thiazolidinone derivatives were then treated with phenyl sulphonamide diazonium chloride yielded the compounds (N-(2-(5-arylfuran-2-yl)-4-oxo-5-(2-(4sulfamoylphenyl) hydrazono) thiazolidin-3-yl) isonicotinamide (5a-e). The structures of these series of heterocycles were assigned by analytical and spectral feature. All the were also evaluated for their antibacterial and antifungal activities.

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4-Amino-1,2,4-traizol (I) on condensation with 5-Phenyl substituted-2-furan carboxaldehyde (IIa-e) yield schiff bases namely N-[(5-Arylfuran-2-yl)methylen]-4H-1,2,4-triazol-4-amine (IIIa-e). Each of schiff base on cyclization with Thioglycolic acid afforded 2-(5-Arylfuran-2-yl)-3-(4H-1,2,4-triazol-4-yl) thiazolidin-4-one (IVa-e). Following this mannich base reaction of each IVa-e with Formaldehyde and Piperidine give 2-(5-Arylfuran-2-yl)-5-(piperidin-1-yl methyl)-3-(4H-1,2,4-triazol-4-yl)thiazolidin-4-one (Va-e). All the compounds of each series were characterized by spectral features and elemental contents. The compounds were also screened for their antimicrobial behavior.