The microspheres are one of the novel drug delivery system in which effective therapeutic alternative to conventional or immediate release single-unit dosage forms. Microspheres can be characterized as solid, diameter having between 1–1000μm.there are different types of microsphere explained. These microspheres prepared and fill them in a hard gelatin or compress them directly. The microspheres which are prepared by using different technique that are changes their effectiveness and administration of the dosage form as compare to conventional dosage form. Microsphere will be evaluated by using different methods that analyses quality of the microsphere. The microspheres which will get central place in novel drug delivery in future.

Multiple emulsions are dynamic hetero-dispersed structures in which water concurrently occurs water in oil and oil in water emulsion both controlled by lipophillic and hydrophilic surfactants. The combination of all such surfactants is useful in stabilizing multiple emulsions. Multiple emulsions include water-in-oil-in-water (w / o / w) and oil-in-water-in-oil (o / w / o) type; the former has extensive formulation, preparation techniques, and multiple-emulsion in-vitro analysis methods are checked. With specific reference to multiple emulsions of the w / o / w, different factors influencing the stability of multiple emulsions and stabilize strategies are discussed in detail. It finds wide range of applications in Multiple emulsions in cancer therapy, Multiple emulsions in herbal medicines, Vaccine / adjuvant, Oxygen replacement, Inverse targeting, Multiple diabetes emulsions, Multiple emulsions in food, Drug over doses treatment, etc. In the course of such microencapsulation a few emulsions were also used as an intermediate step in the process of such microencapsulation and are the structures of growing interest in the oral delivery of hydrophilic drugs that become unstable in gastrointestinal tracts such as proteins and peptides. Stability a with developing preparation methods, drug release tests, in vitro release studies, globule size or particle size, stability and rheological characterization of multiple emulsions, will be able to provide a novel carrier mechanism for medicines, cosmetics and pharmaceutical agents.

Niosomes are non-ionic surfactant-based multilamellar or unilamellar vesicles in which an aqueous solute solution is completely encapsulated by a membrane formed by surfactant macromolecules organised as a bilayer. Because vesicles are made up of a bilayer of non-ionic surface-active substances, the term "Niosomes" was coined (non-ionic surfactants). Niosomes are an unique drug delivery technology that encapsulates the medication in a vesicle. Ionic drug carriers are hazardous and inappropriate, whereas niosomal drug carriers are less dangerous. Niosomes do not require any specific handling or storage conditions.Niosomes have shown to be a promising drug carrier, with the potential to minimise medication side effects and improve therapeutic efficacy in a variety of disorders. Drug insolubility, instability, limited bioavailability, and fast degradation are all issues that niosomes address. The benefits, preparations, assessment, and medicinal uses of niosomes are discussed in this review article.

Recent developments in nanotechnology have made the framework for the growth of new nanoscale biomaterials with numerous potential uses in nanomedicine. The nanosponge is a new and emerging technology that can be used to target medicine delivery in a precise and regulated manner. Nanosponge is an important component of advanced medication delivery. It is a specialized assisting system for regulated medication delivery of both lipophilic and hydrophilic medicines in a regulated manner. Effective medication delivery at a specific location allowed for more exact control of release rates and boosted health-care system compliance, but the chemistry having complex shape complicated things. The invention of nanosponges, on the other hand, has provided significant approach to tackling this problem. The technology of Nanosponge has been studied widely for the delivery of drugs for oral, topical, and parental administration. Enzymes, proteins, vaccines, and antibodies can all be delivered effectively using nanosponges. It is more effective for targeted drug delivery systems because it improves solubility, bioavailability, and decreases side effects by releasing the drug at specific site. It has the ability to improve drug solubility and can be manufactured into oral, topical, and parenteral dose forms. This type of carrier system is best for drugs with low bioavailability. Nanosponges can contain both lipophilic and hydrophilic medicines. Nanosponges are extremely permeable, with a high proclivity for ensuring dynamic particles and programmable delivery. This review article discusses nanosponges in general, their advantages & disadvantages, mechanism; factors influence nanosponge, preparation methods, evaluation parameters as well as applications.