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The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

Naturally occurring or synthetic androgenic substances injected into adult rats shortly after hypophysectomy will cause varying degrees of tubular maintenance in the testes,'-5 but the interstitial cells are not prevented from undergoing After tubular atrophy in hypophysectomized rats has occurred, it has not been possible to restore spermatogenic activity by means of andro-gen~.'-~ Maintenance of spermatogenesis in hypophysectomized rats by androgens has not as yet been satisfactorily explained. The possibility that androgens have only an indirect effect on the germinal epithelium, scrota1 maintenance being of prime importance,s* has not been accepted by Nelson and M e r~k e l .~ Incontestable evidence that male hormones have a direct or only an indirect effect on spermatogenesis is still lacking.It has seemed of importance in view of our present lack of understanding with regard to the r d e played by androgens in spermatogenesis to study the effects of male hormones in immature hypophysectomized rats. This has seemed especially important since it has been shown that bull testis extracts' and andro~terone~ cause marked injury to the testicular tubules of young rats. The purpose of this investigation was to discover whether spermatogenesis would occur in immature hypophysectomized rats injected with androgenic substances. As we have never observed sperm heads, as described by Moore,' earlier than the 34th day of life, we selected animals much younger than this to rule out the possibility that sperm 1

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