Dual Endocrine Activity of the Testes

McCullagh, D. Roy

doi:10.1126/science.76.1957.19

Cited by 465 publications

(117 citation statements)

References 1 publication

Supporting

Mentioning

111

Contrasting

Unclassified

Order By: Relevance

“…McCullagh's demonstration of the suppression of anterior pituitary or 'castration' cells by bovine testicular fluid raised the idea that the FSH system was subject to endocrine influences beyond those that were already recognised (McCullagh 1932).…”

Section: Defining Prostatic Inhibinmentioning

confidence: 99%

The role of inhibins and activins in prostate cancer pathogenesis.

Dowling¹,

Risbridger²

2000

Endocrine-Related Cancer

View full text Add to dashboard Cite

Successful prostate cancer diagnosis and management continue to provide challenges for the clinician. While interventions aimed at the containment of both early and late disease continue to fail in a significant number of patients, the search for answers must incorporate an analysis of the processes of normal and aberrant growth and development within the gland itself. Inhibin and its structurally related protein, activin, are members of the transforming-growth-factor β (TGFβ) superfamily. Originally identified as regulators of FSH, these proteins are now recognised to have widespread biological functions. This might be expected of proteins that are structurally homologous to TGFβ itself, which is recognised to have regulatory roles in both normal and malignant prostate tissue. The aim of this review is to examine the relationship between inhibins, activins and their related proteins and the development of prostate cancer. The homology with TGF, the pluripotent effects of activin on various tissues and the roles for inhibins in ovarian cancer make activins and inhibins candidate growth factors for involvement at multiple sites in the progression from benign disease to cancer. In compiling this review, we aim to delineate the changes in inhibins and activins in this pathway and in doing so implicate their potential roles in the progression of carcinogenesis. We will compare the changes in inhibin and its related proteins in prostate cancer to those that are known in ovarian cancer. We will discuss the similarities and differences between the putative role of activins and TGFβ in prostate carcinogenesis. The importance of this review lies in demonstrating that inhibin, an endocrine hormone, and its related proteins may contribute to endocrine-related cancers, such as that of the prostate gland.

show abstract

Section: Defining Prostatic Inhibinmentioning

confidence: 99%

The role of inhibins and activins in prostate cancer pathogenesis.

Dowling¹,

Risbridger²

2000

Endocrine-Related Cancer

View full text Add to dashboard Cite

show abstract

“…This activity may be a lead in the long search for the substance 'inhibin', which was postulated many years ago to explain the rises in pituitary, urine and plasma FSH after selective destruction of the germinal epithelium (Mottram & Cramer, 1923;McCullagh, 1932;Johnsen, 1964;Van Thiel, Sherins, Myers & DeVita, 1972). Inhibin is thought to be produced by the germinal epithelium in proportion to the rate of sperm production and to act as a negative feed-back on the pituitary production and/or secretion of FSH.…”

Section: Mechanism Of Secretion and Its Controlmentioning

confidence: 99%

Secretions of the Testis and Epididymis

Bp¹

1974

Reproduction

View full text Add to dashboard Cite

“…L'hypoth6se de la s6cr6tion de peptides testiculaires ~ activit4 inhibitrice de la s4cr4tion anteh y p o p h y s a i r e est assez a n c i e n n e [14]. L'isolement et la caract6risation des inhibines ont 6t4 laborieux [22], quelques m 6 t h o d e s de dosage peu sp6cifiques ont e n t r e n u des doutes sur la physiopathologie de cette h o r m o n e [7].…”

Section: Age I N H I B I N E B F S H T E S T O S T 4 R O N E Testo Lunclassified

L'Inhibine B chez les blessés radiculo-médullaires. Résultats préliminaires

Mathian

Pallant

Pilonchery

et al. 1999

Androl.

View full text Add to dashboard Cite

RESUM]~Les l~sions neurologiques constat~es chez les hommes blesses radiculo-m~dullaires entrainent souvent une alteration de la qualit~ du sperme et parfois une an~jaculation. Des biopsies testiculaires ont permis de mettre en ~vidence que ratteinte m~dullaire peut ~tre responsable de l'alt~ration des cellules de la lign~e germinale. Un bilan hormonal a ~t~ pratiqu~ chez 13 patients pr~sentant une absence de sperme au moment de rexamen.

show abstract

Dual Endocrine Activity of the Testes

Cited by 465 publications

References 1 publication

The role of inhibins and activins in prostate cancer pathogenesis.

The role of inhibins and activins in prostate cancer pathogenesis.

Secretions of the Testis and Epididymis

L'Inhibine B chez les blessés radiculo-médullaires. Résultats préliminaires

Contact Info

Product

Resources

About