Chronic Kidney Disease (CKD) exhibits dyslipidemia and oxidative stress which are well known traditional risk factors for vascular complications. Therefore this study was undertaken to assess the lipid profile and oxidative stress in CKD patients. The study comprised of 95 patients with evidence of CKD. These cases were further divided into 2 groups i.e. non dialysis and hemodialysis groups. There is a significant increase of serum triglycerides and Very Low Density Lipoprotein (VLDL) with a decrease in serum High Density Lipoprotein-Cholesterol (HDL-C) in both non dialysis and hemodialysis groups of CKD patients when compared with control. But there is no alteration in serum total cholesterol and Low Density Lipoprotein Cholesterol (LDL-C) in both groups. Serum Malondialdehyde (MDA) was significantly raised and serum Superoxide Dismutase (SOD) was significantly lowered in CKD patients both in non dialysis and hemodialysis groups when compared with control. The same changes in respect of serum Malondialdehyde (MDA) and Superoxide dismutase (SOD) were also noted in hemodialysis group when compared with non dialysis patients. In hemodialysis patients, the alteration was further aggravated after hemodialysis and these changes were found to be significant when compared with those patients before hemodialysis. All these factors are suggestive of abnormal lipid profile and enhanced lipid peroxidation with decreased antioxidant status. This study would be beneficial for patients with CKD especially those under hemodialysis for instituting antilipidemic drugs and antioxidant therapy which will improve the quality of their lives.

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Background: Obesity individual have increased BMI and abnormal lipid profile. The abnormal lipid profile will causes fatty infiltration in the hepatic cells and it will progress towards to fatty liver. Fatty liver is a benign condition it is identified as a main cause for liver related mortality and morbidity. Liver steatosis by ultrasound grading might throw a warning sign of the future risk. Methods: A cross sectional study, containing 60 young adults. In all the subjects, Height was estimated in centimeters and Weight was measured in kilogram on standard clinical weighing machine. BMI was calculated as Weight in kilogram divided by Height in meters squared. They are classified based on BMI and all the individuals liver ultrasound and lipid profile was performed Results: In the present study most of the high BMI subjects have Grade 2 steatosis followed by Grade 1. In BMI greater than 25 group around 56% are belongs to Grade 2 and Grade 3 whereas in case of BMI less than 25 group it is 16%. There is significantly increase of serum triglycerides, cholesterol, VLDL and LDL in BMI greater than 25 group compared to BMI less than 25. Whereas serum HDL was significantly declined in higher BMI. Conclusion:Present study finding suggested that there is a more staetosis in overweight and obese individuals. Ultrasonography guided liver steatosis is a cost effective, noninvasive, easy and reproducible and early intervention prevent worst prognosis.

A series of 5-chloro-1-(piperidin-4-yl)-1H-benzo[d]imidazole-2(3H)-one derivatives have been synthesized and characterized by various spectroscopic techniques including FTIR, mass and 1H NMR. In current study, we have followed standard methods for the synthesis of novel molecules, docking and screening against mycobacterium species. The compounds were docked against 2Q1Y protein by using MCULE software and screened them by MABA. Out of sixteen synthesized molecules, two molecules i.e. DSR-14 and DSR-9 had shown good antitubercular activity.