A Study of Lipid Profile and Lipid Peroxidation in Chronic Kidney Disease with Special Reference to Hemodialysis,

Abstract

Chronic Kidney Disease (CKD) exhibits dyslipidemia and oxidative stress which are well known traditional risk factors for vascular complications. Therefore this study was undertaken to assess the lipid profile and oxidative stress in CKD patients. The study comprised of 95 patients with evidence of CKD. These cases were further divided into 2 groups i.e. non dialysis and hemodialysis groups. There is a significant increase of serum triglycerides and Very Low Density Lipoprotein (VLDL) with a decrease in serum High Density Lipoprotein-Cholesterol (HDL-C) in both non dialysis and hemodialysis groups of CKD patients when compared with control. But there is no alteration in serum total cholesterol and Low Density Lipoprotein Cholesterol (LDL-C) in both groups. Serum Malondialdehyde (MDA) was significantly raised and serum Superoxide Dismutase (SOD) was significantly lowered in CKD patients both in non dialysis and hemodialysis groups when compared with control. The same changes in respect of serum Malondialdehyde (MDA) and Superoxide dismutase (SOD) were also noted in hemodialysis group when compared with non dialysis patients. In hemodialysis patients, the alteration was further aggravated after hemodialysis and these changes were found to be significant when compared with those patients before hemodialysis. All these factors are suggestive of abnormal lipid profile and enhanced lipid peroxidation with decreased antioxidant status. This study would be beneficial for patients with CKD especially those under hemodialysis for instituting antilipidemic drugs and antioxidant therapy which will improve the quality of their lives.

A study of lipid profile in chronic kidney disease in pre- dialysis patients

“…This is in concordance with the present study as the Study group comprised of patients in CKD stages 3 to 5 only. CKD patients obtained significant increase in TG and VLDL-C levels and statistically significant decrease in HDL-C levels, but no change in TC and LDL levels [8].…”

“…The prevalence of hyper-cholesterolemia ranges from 48% in CKD stage 1-2 to 80% in CKD stage 3-4 [3]. Several prospective studies suggest that lipid abnormalities principally present in CKD is Hypertriglyceridemia along with increased Very-Low Density Lipoprotein Cholesterol (VLDL-C) and decreased HDL-C [8]. Abnormal lipid and lipoprotein concentrations in patients with CKD may be responsible for increased atherosclerosis and risk of CVD [9].…”

Association of MMP‐9 gene polymorphisms with nephrolithiasis patients

“…[36][37][38] On top of that, other studies noted that lipid peroxidation causes tissue damage due to the development of different diseases like atherosclerosis, and is related to the increase of cardiovascular mortality and morbidity in CKD. 39,40 This study demonstrated that the serum concentration of TOS, MDA, OSI TAS and uric acid statistically differed in patients with nephrolithiasis.…”

To Analyse the Pattern of Lipid Profile in Patients of Chronic Kidney Disease

“…"Disturbances of lipids in CKD may have huge effect, chances for CVD at a special note. [49] The study by Khatiwada et al, [48] suggested the significant association between the presence of cardiovascular disease with hypercholesterolemia and high LDL cholesterol in CKD patients. Our study reveals that CKD progression is strongly associated with CVD prevalence.…”