Introduction: In woman's life menopause can cause psychological and somatic disturbances. Psychological and behavioural intervention is effective in reducing menopause-related symptoms. Aims: The present study was done to find effectiveness of mindfulness-based cognitive behavioural therapy (MBCT) on quality of life among menopausal women. Methods and Material: The present study was double-blind randomized trial conducted among menopausal women at tertiary care hospital, Chennai, Tamil Nadu. The study was conducted among 50 women who had attained menopause. They were randomly divided into intervention (n = 25) and control (n = 25) groups. The MBCT was given once a week to intervention group over eight one-hour sessions and control group received no intervention. The data collection instruments included a demographic questionnaire, Kupperman's index, and menopause-related quality of life questionnaire, which were fulfilled by both groups before, immediately after, and 2 weeks after completion of intervention. Paired t-test was applied before intervention and at 10 weeks for both the groups. Results: The difference between the scores before and after intervention i.e after 10 weeks in all the domains and total domain was significant in intervention group compared to control group. Conclusions: Mindfulness based approaches may improve severity of vasomotor and psychological symptoms of menopause, thus enhancing quality of life.

Background: Antiretroviral drugs delay progression of HIV disease and improve the quality of life in the HIV infected people. A very high levels of adherence is required for ART to be effective long term and to prevent the emergence of resistant viral strains. The objectives were to assess the adherence of anti-retro viral treatment and its determinants and to estimate the status of CD4 count before and after ART in HIV patients.Methods: The study was a cross sectional study conducted in ART center Hamidia hospital at Bhopal, Madhya Pradesh. 256 participants with HIV who had registered in the center and receiving ART for the past 6 months were included in the study. A predesigned questionnaire was used for the study. Data was analysed using Epi Info. The significance of proportion were calculated using chi square test (p<0.05).Results: All the respondents knew that unprotected sexual contact, contaminated Blood transfusion and infected syringes were the major modes of transmission of HIV. About 60 (41.96%) in 143 patient with CD4 count <200 improved to >350. Majority of respondents 195 (76.17%) missed the dose often and 61 (23.83%) did not miss the dose at all. The major reasons for missing dose of ART regimen were forgot to take medicines (57.95%), alcoholic state (26.15%) and long duration of treatment (47.17%).Conclusions: The majority of patient missed the doses due to socio demographic and treatment related factors. A good treatment adherence is linked with the good quality drug and better environment in the clinics throughout the treatment period.

Background: To assess and compare the efficacy, safety and fetomaternal outcome of mifepristone versus dinoprostone in priming the cervix and in inducing labour in pregnant women at term.Methods: This is a prospective comparative study done in Chettinad health and research institute, over a period of one year from October 2015 to October 2016. 50 pregnant women (Group 1) in 3rd trimester with unfavorable cervix were given 200mcg of mifepristone orally. If labour did not start or if the Bishop score remained poor at the end of 24hrs, induction was continued with 0.5mg of dinoprostone gel at a maximum of 3 gels at 6th hourly interval. Another 50 pregnant women (Group2) in 3rd trimester underwent induction according to the routine dinoprostone gel regimen of maximum 3 gels at intervals of 6hrs.Results: Improvement in Bishop score was significant with mifepristone by the end of 24hrs.But, in comparison, there was statistically significant improvement in Bishop score in favour of dinoprostone (Mean 4.7) than mifepristone (Mean 4.0). Also, the induction delivery interval was significantly less (Mean 11.5 hrs) with dinoprostone than mifepristone (Mean 20.3 hrs). Number of cases undergoing LSCS for failed induction was less in mifepristone group (4%). The rate of vaginal delivery, Caesarean sections, instrumental delivery and overall fetal outcome was comparable in both groups.Conclusions: Mifepristone is a safe, effective and suitable alternate agent for cervical ripening and initiation of labour when given 24 h before onset of labour.