Abstract. T he T ulsa Regi stry of Canine and Fe line Neopl asms was the second anima l tumor regist ry in the U nited Sta tes conce rned with a defin ed populati on in a delimited geographic area . Only tumors histo logica lly confi rmed by registry pa tho logists were incl ude d in freq uenc y statistics based on the ann ua l dog and ca t pop ulatio n present ed to veterinarians .During the first registry year, abo ut 1% of the 63,504 dogs and 0.5% of the 11,909 cats had one or more primary tum or s. While the incidence ra te for ma lignan t tu mor s in dogs was similar to th at in cat s, the incidence of benign tumors of dogs was ove r 10 times that of cats . The most commo n tum ors were sebaceous adenoma in dogs and lymp hosarcoma in cats. Mammary cancer was the most commo n malignant tu mor in dogs . Mammary tumo rs of fema le dogs were significantly more frequent in Poi nte rs, Poodl es and Boston Te rrie rs, in that order , than in other breeds. A greater incidence of mam ma ry tumors amo ng intact compa red to spa yed fema le dogs was seen for virtually every age grou p except in the Pointer breed .In veterinary medicine, the lack of census, certification of death, and registries of neoplasms have precl uded epidemiological studies compa ra ble to those of neopl asms of man . Because of di fferent organizatio nal struc tures and de fined reference populations, ani mal neoplasm registries have different limitations. Animal tum or registry statistics based upon estimated populations derived from enumera tion of licensed or vaccina ted ani mals [2,8,17] have suffered from populati on (deno mina tor) und erestimation beca use of the low response of the public in licen sing or vaccinating thei r pets. Ot her tu mor registries based on submissions to veterina ry medical teaching hospitals [3,12] are no t representa tive of the tum or cases (nume rators) becau se of referrals and the lack of clear defi nition of the geographic areas served. In addition to important descriptive informat ion, these studies have provided indications of possible variations in tum or occurrence between broad geographic areas . The variations per ha ps are related to regional differences in breed popularity, in the distributions of other host characteristics such as age or sex or different env iro nme nta l exposures, including veterinary medica l care.The first registry based on collections of tumo rs submitted from all veterinary hospitals within a defi ned geographic region was esta blished in 1963 in California 70 0

Leishmaniasis of man is an endemic, sporadic infection in Central and [4-7, 9, 12, 131. All were in dogs with a history of travel in Greece for extended periods. A fox in a zoo probably acquired leishmania1 infection in Northern Africa [3]. We report the discovery of an endemic focus of canine leishmaniasis in north central Oklahoma.A 7-year-old female American Foxhound dog, had had alopecia of 90% of its body for about a year and Demodex mites had been found repeatedly in skin scrapings. It had come from a kennel of 17 Foxhounds, about half of which had dermatitis characterized by dry hair coat, scaliness, moderate to severe randomly distributed alopecia, moderate erythema, some pruritis and ulceration with exudation.The dog was anemic (packed cell volume, 28.0%) and had a slightly elevated leukocyte count (18,100 WBC/mm3) and neutrophilia (90%). Total serum proteins were 9.5 gm/dl. Blood urea nitrogen, serum glutamic pyruvic transaminase, and glucose were within normal limits. Serum electrophoresis revealed hypoalbuminemia (I. 16 g/dl), hyperglobulinemia (7.84 g/dl) and an albumin/globulin ratio of 0.15.The dog was killed and necropsied. It was thin with prominent bony structure and generalized muscle atrophy. There was complete generalized hair loss except on the dorsal midline. Multiple scabs and areas of ulceration with exudation were on the face, neck and about the ears. The popliteal, prescapular, and superficial inguinal lymph nodes were enlarged. Bone marrow was deep red and wet. The lungs contained several irregular, slightly elevated pale areas, about 1 centimeter at greatest width, that extended slightly into the parenchyma. There was serous atrophy of fat associated with joints and heart. Impression smears of a prescapular lymph node and bone marrow taken at necropsy had numerous leishmania within macrophages ( fig. 1). Organisms were found in sections of hilar, mesenteric, popliteal and prescapular lymph nodes. Cortical and medullary areas contained diffuse, often dense, accumulations of macrophages which contained many organisms. Accumulations of plasma cells were associated with reticuloendothelial proliferation.Organisms also were in macrophages associated with diffuse septa1 thickening and multifocal areas of plasma cells and histiocytes in lung. Macrophages in the red pulp of the spleen, Kupffer cells and periportal macrophages of the liver, macrophages in the lamina propria and submucosa of stomach, duodenum, jejunum, ileum, and colon all contained leishmania. A few macrophages with organisms were in connective tissue of the right and left atrium and of the inner renal medulla. All sections of skin contained numerous organisms in macrophages throughout the superficial and deep dermis. Organisms were within and without areas of

Abstract. Ductal carcinomas accounted for nearly all metastases seen in epithelial canine mammary tumors submitted to the Tulsa Registry of Canine and Feline Neoplasms in a 4-year period from a defined canine population. Lobular and squamous cell carcinomas were the only other metastatic carcinomas seen. Early ductal carcinoma was used to indicate nonmetastatic ductal carcinoma with a favorable post-surgical prognosis. Benign epithelial tumors were categorized as adenoma, ductal papilloma and squamous cell papilloma. Progressive transformation of well defined adenomas and papillomas to carcinoma was not evident in histologic preparations.Squamous metaplasia was seen in many ductal papillomas and ductal carcinomas. Inclusion of pseudocartilage and pseudoosteoid and osteoid, cartilage and bone with ductal carcinomas, adenomas and ductal papillomas seemed related to secretions escaping from neoplastic epithelial cells into stroma or between proliferating tumor cells. There was proliferation and perhaps even neoplastic transformation of myoepithelial cells in some of these tumors. Changes in myoepithelium, however, appeared to be secondary to neoplastic transformation of epithelium. Bone and cartilage in these tumors were considered heterotopic with no neoplastic potential.

Four species of sandflies: Phlebotomus (Larroussius) perniciosus Newstead, Sergentomyia minuta (Rondani), Phlebotomus (Paraphlebotomus) sergenti Parrot and Phlebotomus (Larroussius) ariasi Tonnoir, were collected, by aspiration and light traps, from three dog kennels and an area of high prevalence of human and canine visceral leishmaniasis in the Algarve, Portugal. Midgut infections with leishmanial promastigotes were observed only in P. perniciosus with a minimum infection rate of 5%. The engorgement, gravidity, population dynamics and sex ratios of the sandflies, and the temperature, source and altitude of collection sites were examined. Host preferences were noted for P. perniciosus.