Frequency of Canine and Feline Tumors in a Defined Population

Abstract

Abstract. T he T ulsa Regi stry of Canine and Fe line Neopl asms was the second anima l tumor regist ry in the U nited Sta tes conce rned with a defin ed populati on in a delimited geographic area . Only tumors histo logica lly confi rmed by registry pa tho logists were incl ude d in freq uenc y statistics based on the ann ua l dog and ca t pop ulatio n present ed to veterinarians .During the first registry year, abo ut 1% of the 63,504 dogs and 0.5% of the 11,909 cats had one or more primary tum or s. While the incidence ra te for ma lignan t tu mor s in dogs was similar to th at in cat s, the incidence of benign tumors of dogs was ove r 10 times that of cats . The most commo n tum ors were sebaceous adenoma in dogs and lymp hosarcoma in cats. Mammary cancer was the most commo n malignant tu mor in dogs . Mammary tumo rs of fema le dogs were significantly more frequent in Poi nte rs, Poodl es and Boston Te rrie rs, in that order , than in other breeds. A greater incidence of mam ma ry tumors amo ng intact compa red to spa yed fema le dogs was seen for virtually every age grou p except in the Pointer breed .In veterinary medicine, the lack of census, certification of death, and registries of neoplasms have precl uded epidemiological studies compa ra ble to those of neopl asms of man . Because of di fferent organizatio nal struc tures and de fined reference populations, ani mal neoplasm registries have different limitations. Animal tum or registry statistics based upon estimated populations derived from enumera tion of licensed or vaccina ted ani mals [2,8,17] have suffered from populati on (deno mina tor) und erestimation beca use of the low response of the public in licen sing or vaccinating thei r pets. Ot her tu mor registries based on submissions to veterina ry medical teaching hospitals [3,12] are no t representa tive of the tum or cases (nume rators) becau se of referrals and the lack of clear defi nition of the geographic areas served. In addition to important descriptive informat ion, these studies have provided indications of possible variations in tum or occurrence between broad geographic areas . The variations per ha ps are related to regional differences in breed popularity, in the distributions of other host characteristics such as age or sex or different env iro nme nta l exposures, including veterinary medica l care.The first registry based on collections of tumo rs submitted from all veterinary hospitals within a defi ned geographic region was esta blished in 1963 in California 70 0

Estudo retrospectivo de 761 tumores cutâneos em cães

“…Os tumores de pele corresponderam a 67,6% e 44,8% de todos os tumores diagnosticados nessas espécies, respectivamente (DORN et al, 1968a;DORN et al, 1968b). Em outro estudo, realizado no estado norteamericano de Oklahoma, a prevalência de tumores em cães e gatos foi de 1.126 e 470 novos casos/100.000/ ano, respectivamente (MacVEAN et al, 1978).…”

Effect of age on liver pathology and other diseases in flatfish: implications for assessment of marine ecological health status

“…Furthermore, they state that, with the exception of virus-induced cancers in woodchuck and in rodents and due to difficulties in estimating population size in most wild animals, cancer has not been reported as a major cause of mortality in wild animal populations. In this context, since reports of cancer prevalence in captive or domesticated animals may be artificially inflated due to increased lifespan or veterinary intervention to extend life in the animals (MacVean et al 1978, Priester & McKay 1980, Fowler 1987, the 27% of beluga exhibiting cancer in the St. Lawrence estuary population was considered to represent a higher propensity for cancer in animals from this site compared to that observed in other open-water populations of the same cetacean species, or in humans or domesticated animals. In this instance, the highest risk factor was considered to be exposure to carcinogenic contaminants present in the sediments and infauna of the estuary (Martineau et al 2002), a similar conclusion to that for the cause of liver neoplasms in estuarine flatfish (Myers et al 2003).…”

Mutations of the p53 gene in canine lymphoma and evidence for germ line p53 mutations in the dog

“…However, the status of the p53 gene in canine lymphoma is unknown. Lymphoma represents 6% of canine malignant cancers (MacVean et al, 1978). It is clinically and morphologically similar to human non Hodgkin's lymphoma and may represent an attractive clinical model for investigations of cancer treatment and prevention (Carter et al, 1986;Greenlee et al, 1990).…”