The worldwide spread of the SARS-CoV-2 virus poses unprecedented challenges to medical resources and infection prevention and control measures around the world. In this case, a rapid and effective detection method for COVID-19 can not only relieve the pressure of the medical system but find and isolate patients in time, to a certain extent, slow down the development of the epidemic. In this paper, we propose a method that can quickly and accurately diagnose whether pneumonia is viral pneumonia, and classify viral pneumonia in a fine-grained way to diagnose COVID-19. Methods: We proposed a Cascade Squeeze-Excitation and Moment Exchange (Cascade-SEME) framework that can effectively detect COVID-19 cases by evaluating the chest x-ray images, where SE is the structure we designed in the network which has attention mechanism, and ME is a method for image enhancement from feature dimension. The framework integrates a model for a coarse level detection of virus cases among other forms of lung infection, and a model for fine-grained categorisation of pneumonia types identifying COVID-19 cases. In addition, a Regional Learning approach is proposed to mitigate the impact of non-lesion features on network training. The network output is also visualised, highlighting the likely areas of lesion, to assist experts' assessment and diagnosis of COVID-19. Results: Three datasets were used: a set of Chest x-ray Images for Classification with bacterial pneumonia, viral pneumonia and normal chest x-rays, a COVID chest x-ray dataset with COVID-19, and a Lung Segmentation dataset containing 1000 chest x-rays with masks in the lung region. We evaluated all the models on the test set. The results shows the proposed SEME structure significantly improves the performance of the models: in the task of pneumonia infection type diagnosis, the sensitivity, specificity, accuracy and F1 score of ResNet50 with SEME structure are significantly improved in each category, and the accuracy and AUC of the whole test set are also enhanced; in the detection task of COVID-19, the evaluation results shows that when SEME structure was added to the task, the sensitivities, specificities, accuracy and F1 scores of ResNet50 and DenseNet169 are improved. Although the sensitivities and specificities are not significantly promoted, SEME well balanced these two significant indicators. Regional learning also plays an important role. Experiments show that Regional Learning can effectively correct the impact of non-lesion features on the network, which can be seen in the Grad-CAM method. Conclusions: Experiments show that after the application of SEME structure in the network, the performance of SEME-ResNet50 and SEME-DenseNet169 in both two datasets show a clear enhancement. And the proposed regional learning method effectively directs the network's attention to focus on relevant pathological regions in the lung radiograph, ensuring the performance of the proposed framework even when a small training set is used. The visual interpretation step using Grad-CAM finds ...

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The intricate anatomy of the eyelid, and the subspecialization trend in pathology made it more difficult for general surgical pathologists to maintain high accuracy across the entire range of diverse eyelid lesions. A lack of access to subspecialty expertise, and misalignment of diagnosis for eye pathology can slow diagnostic speed, resulting in intraorbital and intracranial extension and/or systemic spread which could threaten vision and life. Here, we developed a robust diagnostic deep learning system (DLS) to detect eyelid tumors using digital histopathological sections based on 473,037 pathological patches from 794 haematoxylin-eosin [H&E] stained whole slide images (WSIs) from two hospitals. This 9-class diagnosis task included top five benign and four malignant eyelid tumors. We first proposed a cascade-network instead of single network, to use the features from both histologic pattern and cellular atypia in a holistic pattern. Our model utilizing cascade-network design achieved 1.0 and 0.946 accuracy in the test and independent test set, respectively, for benign and malignant binary classification; without cascade-network design, accuracy was 0.957 and 0.887, respectively. For multiple classification of individual disease, the DLS with cascade-network design achieved 0.989 and 0.931 overall accuracy for WSI diagnosis in the test set (9-class) and independent test set (8-class) respectively, while without cascade design achieved 0.774 and 0.662. In conclusion, this DLS, using cascade-network design, can automatically detect malignancy in histopathologic slides of common eyelid tumors with a high degree of accuracy, which also has potential to augment histopathological diagnosis for a wide range of tumors.

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