Introduction: The effects of aerobic exercise on the immune system are not yet fully defined in the scientific literature. This fact demonstrates the need to investigate its influence on existing immunological markers by classifying and quantifying their acute and chronic effects. Objective: To investigate the effects of acute and chronic aerobic exercise on inflammatory markers of healthy adults. Methods: This study is a systematic review according to PRISMA recommendations. The following databases were searched: MEDLINE (via PubMed), Science Direct, Scopus, Web of Science, SciELO, Bireme and Cochrane Library, and article references. The last search was performed in March 2019. We included randomized controlled trials (RCTs) and non-randomized controlled trials (NRCTs) investigating the acute and chronic effects of aerobic exercise on immune markers in healthy male and female adults aged 20 to 45 years, without restrictions in language or year of publication. Two authors independently analyzed the studies by reading the titles, abstracts, and full texts. Risk of Study bias was analyzed using Cochrane's Risk of Bias Tool. Outcomes: We included 15 studies in this systematic review, 13 of which were acute intervention and 2 were chronic, with 296 participants, 196 men and 100 women all being healthy individuals. It was observed that the acute intervention promotes changes in most immunological markers, while the chronic intervention interferes with a smaller proportion, this being in lymphocyte subpopulations. In the evaluation of quality, it was found that most studies did not present a high risk of bias in the evaluated aspects, but an unclear related risk of bias was observed, requiring a more careful analysis. Conclusion: Thus, it can be concluded that the evidence indicates that acute and chronic interventions may modify most immune markers, but aspects such as gender, contraceptive pill use in women, physical capacity of the investigated individuals, environment, and type and intensity of the exercises may interfere with these markers as well as the data analysis. Therefore, this review suggests that further research is needed to contribute to the confirmation and estimation of results.

Estudo epidemiológico e de concordância diagnóstica entre a citologia, colposcopia e histopatologia, em pacientes com diagnóstico de Papilomavírus Humano.Epidemiological study and diagnostic compatibility among cytology, colposcopy and histopathology in patients with Human Papillomavirus diagnosis. ABSTRACTThe diagnosis of intraepithelial lesions and carcinoma of the cervix is performed by combining three methods, namely cytology, colposcopy, and histology. The present study represents a retrospective and descriptive cross-sectional epidemiological study of patients' charts with cytological and colposcopic findings compatible with HPV infection, at the Potengi Clinic, in the year 2012 (Natal/RN). We analyzed 111 medical records of patients diagnosed with HPV and the data collected were age, menarche, the onset of sexual life, marital status, sexual partners, contraceptive methods used and results of cytological, colposcopic and histopathological exams. Patients had a mean age of 30 years, most of whom were married (71.2%), menarche at 12-year-old, and sexual debut at approximately 17 years, with a mean of 9.4 partners. About 38% of them use oral contraceptives, 37% do not use any method and only 10% use condoms. The concordance between cytology and colposcopy and between cytology and histology was very significant (rs=0,953; p<0,05). From the analysis of the present study, it can be concluded that the association of cytological, colposcopic and histological methods is more efficient in the diagnosis of lesions caused by viruses such as HPV and carcinoma and should, therefore, be used together. RESUMOO diagnóstico das lesões intraepiteliais e do carcinoma do colo uterino é realizado mediante a associação de três métodos, que são a citologia, colposcopia e histologia. O presente estudo representa uma pesquisa epidemiológica transversal retrospectiva e descritiva de prontuários de pacientes com achados citológicos e colposcópicos, compatíveis com a infecção por HPV, atendidas na clínica Potengi, no ano de 2012 (Natal, RN). Foram analisados 111 prontuários de pacientes diagnosticadas com HPV e os dados coletados foram idade, menarca, início da vida sexual, estado civil, parceiros sexuais, métodos contraceptivos utilizados e resultados de exames citológicos, colposcópicos e histopatológicos. As pacientes tinham média de idade 30 anos, sendo a maioria casada (71,2%), com menarca aos 12

Obesity represents a risk factor for the emergence of chronic non-communicable diseases, such as Diabetes Mellitus and cardiovascular diseases. Adequate monitoring of blood glucose and lipid profile has been shown to be protective factors for the onset of these diseases. Some preparations based on carbohydrates are part of the culture of the northeast region of Brazil and, depending on how they are consumed, they can trigger different responses to the organism. This study evaluated the glycemic response and the concentration of some plasma fats after intake of preparations with added fibers and/or proteins. The BMI of the participants was calculated and the informed consent form and the FFQ were completed. Blood sampling was performed before food tasting. One hour after food intake, the blood collection procedure was repeated. It was found that, in the preparations with addition of fibers and/or proteins, there was less glycemic response in comparison to the food consumed alone; moreover, there were changes in the lipid profile. Thus, considering the addition of fibers and proteins to these preparations can be an interesting strategy for nutritional management