Objective: This study aimed to evaluate metabolic syndrome prevalence among traders women leaving in Yaounde, Cameroon. Methods:The study was conducted on one hundred and sixteen women aged between18-60 years who were referred to the Andre

Objective: This study aimed to evaluate the metabolic syndrome among Mbo ethnic group women living in Yaounde, Cameroon. Methods: The study was conducted on ninety-two women aged between 18-60 years who were referred to the Andre Fouda Medical Fundation in Yaounde. Metabolic syndrome was diagnosed using Adult Treatment Panel-III (ATP-III) 2001 guidelines. Results: The mean of age, high fasting blood glucose, triglycerides levels and total cholesterol levels were significantly (p<0.05) higher in women with metabolic syndrome. The overall prevalence of metabolic syndrome among Mbo women was (3.03%). High blood pressure level (43.93%) and high fasting glucose (14.39%) were respectively the most frequent characteristics in comparison to other metabolic components. 3.03%, 0% and 0% had three, four and five criteria for metabolic syndrome, respectively. Conclusion: The prevalence of metabolic syndrome is low in women originates of Mbo ethnic group of Yaounde. For efficient measures to limit the rise of cardiovascular diseases in these women, both hypertension and hyperglycaemia should be taken into consideration.

Prediabetes is a known risk factor for type 2 diabetes and lead to long term complications such as cardiovascular diseases. In Cameroon, they are limited data dealing with prediabetes prevalence among Cameroonians. Our study objective was to estimate the prevalence of metabolic syndrome among prediabetic women and normoglyceamic women. Methods:A total of 200 women (100 prediabetic women and 100 normoglyceamic) participated in the study, they were aged between 20-55 years. For their studied data, they were referred to the Andre Fouda Medical Fundation in Yaounde. Metabolic syndrome was diagnosed using Adult Treatment Panel-III [ATP-III] 2001 guidelines and prediabetes was defined as impaired fasting plasma glucose ranged between 6.1-6.9 mmol/l. Results:The frequency of various cardiovascular risk factors was not different among the two group of study; only fasting blood glucose was significantly high among prediabetics compared to normoglyceamics women. The mean age in prediabetic women was 34.34 ± 8.96 years and 35.48 ± 9.88 years among normoglyceamic women. Among the prediabetic population, a total 61% of patients had hyperglyceamia, 59% had hypertension, 58% had increased waist circumference and 56% were diagnosed with metabolic syndrome. The most common abnormalities in normoglyceamic women was hypertension (58%), increased waist circumference (53%) and low HDL (52%). Metabolic syndrome was diagnosed in 23% of normoglyceamic women. Prediabetics women had a relative high risk of metabolic syndrome 2.43 compared to normoglyceamics women. Conclusion:This study shows that prediabetes is associated with increased prevalence of metabolic syndrome among Cameroonian women. Lifestyle interventions and medication should be instituted to avoid complications among prediabetes.

Background Lipotropic molecules are effective therapeutic targets to counteract non-alcoholic fatty liver disease (NAFLD). Lipotropic compounds are capable of removing fat from the liver and/or manage the reduction of the synthesis or deposition of lipids in the liver. The objective of this study was to evaluate the lipotropic effects of the aqueous extract of leaves of Vernonia guineensis (AEVG) on rats fed high fat diet. Methods Twenty male rats with an average mass of 235 g were allow acclimatize for seven days, following which they were divided into four groups of five animals each. The test group was treated with high fat diet (HFD) and AEVG at 400 mg/kgBW, while positive control group received HFD and Fenofibrate at 100 mg/kgBW. The normal control group received a normal diet; and the negative control group received HFD. After 14 days of treatment, animals were sacrificed, blood and organs (liver, heart and kidneys), as well as the faeces were collected for the preparation of plasma and homogenates respectively. Some markers of lipid profil (total cholesterol, triglycerides, HDL-c, LDL-c,) and markers of toxicity (AST, ALT, γ-GT, creatinine) were evaluated. Results The results obtained showed that a HFD at the hepatic level led to the accumulation of lipids (triglycerides (TG) and total cholesterol (TC)) and had adverse effects on hepatic function by promoting cytolysis. At the plasma level, HFD induced hyperlipidemia. Administration of AEVG at 400 mg/kgBW improved the blood lipid profile and reduced the storage of TG and cholesterol in the liver. AEVG also promoted fecal cholesterol excretion and reduced atherogenic indices which include Total Cholesterol/High-Density Lipoprotein cholesterol (TC/HDL-c) and Low-Density Lipoprotein cholesterol/High-Density Lipoprotein cholesterol (LDL-c/HDL-c). The extract exhibited hepato-protective activity (anticholestasis) and improved glomerular filtration. Conclusion These findings suggest that AEVG possesses lipotropic effects confirming its probable use in the management of non-alcoholic fatty liver disease and its cardiometabolic complications. This virtue could be exploited for local pharmaceutical development.

Bivariate relationships between prediabetes and sex, obesity, age, hypertension was etablished and multivariate logistic regression analyses were used to identified pre-diabetes risk factors. Results: The overall prevalence of prediabetes was (15.03%) higher in women than in men. Through multivariate logistic, it appeared that female sex, overweight/obesity were the risk factors for prediabetes development. Conclusion: The prevalence of prediabetes was high in the studied population of Yaounde. Female sex, overweight, obesity and hypertension were the major risk factors. Public health education to improve awareness