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Baylis–Hillman acetates were conveniently transformed into substituted indenone and piperidine‐2,6‐dione frameworks by treatment with (di)phenylacetonitrile followed by Friedel–Crafts cyclization or imide formation.

An efficient, simple, green, regioselective and catalyst-free synthesis of alkyl-4-(1H-indol-3yl)-2-alkyl-4H-chromene-3-carboxylates is disclosed by employing indoles and substituted chromene derivatives under mild reaction condition. This is a novel green methodology, simple, eco-friendly and easy to operate. Biomass-derived catalyst Water Extract of Lemon (WEL) was used as a promoter for this procedure. The methodology could be applicable for cost-effective large scale production of alkyl-4-(1H-indol-3yl)-2-alkyl-4H-chromene-3-carboxylates in good to excellent yield.

A facile, convenient, and one-pot multi-step synthesis of substituted piperidin-2-ones from the Baylis -Hillman alcohols derived from various aldehydes and acrylonitrile, involving Johnson -Claisen rearrangement, reduction of an a,b-unsaturated nitrile moiety into the saturated amine-skeleton, followed by cyclization, in an operationally simple procedure, is described.Introduction. -In continuation of our interest in the synthesis of heterocyclic molecules [1], we herein report a simple, facile, and one-pot multi-step synthesis of piperidin-2-one derivatives, that is, 5-substituted and 3,5-disubstituted piperidin-2-ones from Baylis -Hillman adducts. The piperidin-2-one moiety occupies a special place in nitrogen heterocyclic chemistry because of the presence of this moiety in a variety of biologically important compounds and therefore, the development of simple procedures for the synthesis of such frameworks is an attractive endeavor in heterocyclic chemistry [2] 1 ).