DNA repeats present in prokaryotes and eukaryotes genomes that include simple tandem repeats, satellite DNA, or palindromic sequences are classified as inverted, direct, and mirror repeats (MRs). Out of these, MRs are not well studied in Drosophila melanogaster Meigen. In this study, manual bioinformatics approach was used to find MRs in D. melanogaster maleless (mle) gene. In this analysis, 123 MRs were found within the complete mle gene, while 78 MRs were found in the exonic region of the mle gene. MegaBLAST was performed to elucidate the presence of identified MRs across the genomes of D. melanogaster, D. nasuta Lamb and D. bipectinate Duda. These demonstrated the conserved characteristics of specific MRs in Drosophila genome and the evolutionary and functional significance of MRs in diverse genomes. This study establishes a link between the presence of MRs in mle gene of D. melanogaster and MRs in human genome.
Genomes of many organisms, including both prokaryotes and eukaryotes, contain numerous repeat elements. Among these DNA repeats, mirror repeats have been studied rarely. Hence, this study on the mirror repeats within the intersex gene of Drosophila melanogaster Meigen, which reveal 11 mirror repeats. Out of these mirror repeats, ten mirror repeats are perfect, and six are within a single exon. The presence of mirror repeats within the intersex gene raises further questions concerning their origin, evolution, and biological function.
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