The aim of this study was to find out absolute values of cerebral oxygenation during uncomplicated anesthesia in otherwise healthy newborns and infants undergoing general surgery and to correlate them with demographic and clinical variables. We examined 10 term newborns and infants ASA class I or II without any documented neurological and cardiovascular disorders. All patients underwent general anesthesia with sevoflurane, fentanyl and muscle relaxants. After induction of anesthesia, near-infrared spectroscopy (NIRS) was started and used throughout the surgery. Overall mean (standard deviation (sd)) rSO 2 value was 84 ± 8% and weakly correlated with weight (r = 0.5), postnatal age (r = 0.2), SpO 2 (r = 0.3) and arterial blood pressure (r = 0.2), p < 0.05 for all variables. We conclude that NIRS is a noninvasive, continuous method for monitoring cerebral oxygenation, simple and easy to perform. Earlier studies and our data suggest that normative values in otherwise healthy term newborns and infants could be weight or age dependant. Further studies are required to assess the clinical value of the routine use of cerebral NIRS in general neonatal and pediatric patient population.