Background: Detection of suicidal ideation (SI) is key for trying to prevent suicide.The aim of this study was to analyze the frequency of SI and related factors in Spanish people with Parkinson's Disease (PwPD) and to compare them with a control group.Methods: PD patients and controls recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. Two visits were conducted: V0 (baseline); V2 (2-year � 1 month follow-up). SI was defined as a score ≥1 on item nine of the Beck Depression Inventory-II (BDI-II). Regression analyses were conducted to identify factors related to SI.

Background: A 61-year-old male patient presented with cerebellar syndrome, which had progressively worsened for 10 days, followed by a tonic-clonic seizure.Phenomenology Shown: Blood analysis showed severe hypomagnesemia and a brain MRI showed T2 hyperintensity in the cerebellar hemispheres (Figure 1). Therefore, the final diagnosis was cerebellar syndrome and epileptic seizures secondary to severe hypomagnesemia. Educational Value:In cases of subacute onset of ataxia, the possibility of ataxia secondary to hypomagnesemia should be considered, as it can be diagnosed with a basic blood test and there are potentially life-threatening outcomes in the absence of treatment, with a reversible course following early supplementation.

Middle Cerebellar Peduncle sign (MCP-sign) is an infrequent finding in brain MRI, usually in the context of neurodegenerative pathologies, considered a classic sign of fragile X-associated tremor ataxia syndrome. Its description in other entities is anecdotal. We present a case of Marchiafava-Bignami Disease (MBD), where reversible hyperintensity in MCP-sign is observed. A 59-year-old male, with history of alcoholism, presented subacute gait disturbance and cognitive deterioration, with progressive worsening over 3 months. On examination, we observed somnolence, dysarthria, cerebellar and sensory ataxia, and cognitive impairment (recovery-memory deficit, executive-attentional dysfunction). Brain MRI showed global thinning of the corpus callosum, T2 hyperintensity at the splenium and MCP-sign; findings described in MBD. The analytical study showed deficiency of folic acid and thiamine. Genetic study ruled out FMR1 premutation. Final diagnosis was probable MBD type B. Treatment with vitamin supplementation showed progressive clinical improvement. A follow-up brain MRI, 2 months after hospital discharge, highlights the resolution of MCP sign, but persistence of the findings in the corpus callosum. MBD is an infrequent pathology, associated with alcoholism and malnutrition, characterized by demyelinating lesions involving the corpus callosum. The few cases described demonstrate a highly variable clinical presentation. The MCP-sign has been described only in a few reports. In our case, good clinical and radiological response stands out after vitamin supplementation. The presence of MCP-sign should also suggest the possibility of MBD, and early vitamin and nutritional assessment should be performed, being an infrequent but treatable entity, with a potentially fatal course in the absence of treatment.

SARS-CoV-2 infection typically produces respiratory manifestations, although multiple neurological manifestations (seizures, stroke, etc.) have also been reported, it is postulated that SARS-CoV-2 (like most β-coronaviruses), has neurotropic potential. We present a case of Probable Parkinson’s Disease (PD) after SARSCoV-2 infection.