The study was mainly aimed to determine the antiurolithiathic potential of different concentrations of E. indica root extract on ethylene glycol induced nephrolithiasis in Rattus norvergicus (albino rats). It specifically targeted the effects the plant extract will pose on serum parameters (creatinine, BUN and uric acid) nitrituria, proteinuria, calcium oxalate excretion, and the histopathology of kidney tubules and glomeruli of albino rats. In the study, root of E. indica was collected, dried and extracted using distilled water of 80°C-100°C. The actual experimental period lasted for 4 weeks. The study involved 5 test groups; negative control group (T -), positive control group or lithogenic group (T + ), two prophylactic groups (T 1 and T 2 ) receiving different concentrations of E. indica root extract (T 1 -500mg/kg and T 2 -800mg/kg) and one curative group receiving 800mg/kg of E. indica root extract after being induced with kidney stones during the first 2 weeks of the experimental period. All the test groups received 0.75% ethylene glycol (stone inducing chemical) in water for 4 week ad libitum with the exception of the negative control. At the end of the study, there was elevated levels of serum creatinine, BUN and uric acid among the lithogenic group which was normalized in all the three treatment groups. There was no significant difference between the serum parameters of the E. indica treatment groups and that of negative control (P < 0.05). There was the presence of nitrituria, proteinuria, high pH and high levels of calcium oxalate excretion in the lithogenic group. But again all these parameters were normalized in the three E. indica treatment groups. E. indica root extract also maintained the normal structure of kidney glomeruli and tubules among T 1 and T 2 (prophylactic groups) and repaired kidney defects in T 3 (curative group). E. indica root extract thus possess antiurolithiathic potentials and can be used to prevent and cure nephrolithiasis in albino rats.