In this paper we investigate the stochastic modelling of a spatially structured biological population subject to social interaction. The biological motivation comes from the analysis of field experiments on a species of ants which exhibits a clear tendency to aggregate, still avoiding overcrowding. The model we propose here provides an explanation of this experimental behavior in terms of "long-ranged" aggregation and "short-ranged" repulsion mechanisms among individuals, in addition to an individual random dispersal described by a Brownian motion. Further, based on a "law of large numbers", we discuss the convergence, for large N, of a system of stochastic differential equations describing the evolution of N individuals (Lagrangian approach) to a deterministic integro-differential equation describing the evolution of the mean-field spatial density of the population (Eulerian approach).

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A major source of complexity in the mathematical modelling of an angiogenic process derives from the strong coupling of the kinetic parameters of the relevant stochastic branching-and-growth of the capillary network with a family of interacting underlying fields. The aim of this paper is to propose a novel mathematical approach for reducing complexity by (locally) averaging the stochastic cell, or vessel densities in the evolution equations of the underlying fields, at the mesoscale, while keeping stochasticity at lower scales, possibly at the level of individual cells or vessels. This method leads to models which are known as hybrid models. In this paper, as a working example, we apply our method to a simplified stochastic geometric model, inspired by the relevant literature, for a spatially distributed angiogenic process. The branching mechanism of blood vessels is modelled as a stochastic marked counting process describing the branching of new tips, while the network of vessels is modelled as the union of the trajectories developed by tips, according to a system of stochastic differential equations à la Langevin.

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An Emergency Medical Service (EMS) plays a fundamental role in providing good quality health care services to citizens, as it provides the first answer in distressing situations. Early response, one of the key factors in a successful treatment of an injury, is strongly influenced by the performance of ambulances, which are sent to rescue the patient. Here we report the research carried on by the authors on the ambulance location and man- agement in the Milano area (Italy), as a part of a wider research project in collaboration with the EMS of Milano and funded by Regione Lombardia. The questions posed by the EMS managers were clear and, at the same time, tricky: could decision making tools be applied, based on the currently available data, to provide suggestions for decision makers? To an- swer such a question, three different studies have been carried on: first the evaluation of the current EMS system performance through statistical analysis; then the study of operational policies which can improve the system performance through a simulation model; and finally the definition of an alternative set of posts through an optimization model. This paper describes the methodologies underlying such studies and reports on how their main findings were crucial to help the EMS in changing its organization model