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Motility disorders are frequent in children with cerebral palsy. The prevalence of gastroesophageal reflux disease varies from the 15% to 75% in patients with cerebral palsy. Nissen fundoplication is the most used antireflux technique not without complications in this population. Our objective was to determine the frequency and the characteristics of the long-term functional and motility complications in patients with Nissen fundoplication and cerebral palsy. A descriptive cross-sectional study was performed. Data collection was acquired retrospectively with neurologic compromise between 2012 and 2017 in patients between 0 to 18 years old, with neurological impairment and Nissen fundoplication. 35 patients were included. Median age was 55 months (2-190). Gastroesophageal reflux disease was diagnosed in the 48%, in the 52% of this the diagnosis was clinical. It was performed by laparoscopic technique in the 91.4% of the cases gastrostomy was done in the same surgical time in 86% of the patients because of neurological impairment and risk of aspiration. In 25.7% (n = 9) there were functional and motor complications, Dumping syndrome (5.5%) accommodation disorders (11.4%) and recurrence of reflux (11.4%). Redo Nissen was required in the 8.5% of the patients (n = 3). In 75% of the patients with complications, gastrostomy was performed in the same surgical time. It could not be demonstrated that gastrostomy at the time of antireflux surgery was associated with greater frequency of complications.