Etodolaclp-cyclodextrin (Eto/p-CD) dispersions were prepared with a view to study the influence of p-CD on the solubility and dissolution rate of this poorly soluble drug. Two systems were used: physicai mixture of Eto/p-CD and kneading solid dispersion of Etolp-CD. Physical characterization of the prepared systems was carried out by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), x-ray, and IR studies. The solubility and dissolution rate of Eto were increased with p-CD physicul mixture as well us with Eto/p-CD kneading solid dispersion. However, enhancement was not statistically different among various cyclodextrin dispersions. 1 I23 Copyright ' i3 1997 by Marcel Dekker, Inc Drug Dev Ind Pharm Downloaded from informahealthcare.com by Michigan University on 11/02/14 For personal use only.

This paper evaluated the potential of zein–resins nanoparticles to act as a carrier for water‐insoluble oil carvacrol. The rosin and shellac were used as natural resins in different mass ratios to plant protein zein. Rosin is one of the natural gums. Shellac is a resinous secretion of the insect. The influence of nanoparticle composition on colloidal properties, encapsulation efficiency, and release of oil was studied. Zeta potential and size of thus prepared nanoparticles were studied. Carvacrol encapsulation efficiency and release were determined by the HPLC method developed for these compounds. Results showed that the resin type and share affect encapsulation efficiency and release of carvacrol. It was also shown that the addition of resins enhanced release from nanoparticles, compared to plain zein nanoparticles. Findings in the present work will help further understanding the interaction between alcohol–soluble biopolymers and provide new insight into the development of natural carriers for bioactive compounds. Novelty impact statement Natural polymers derived from food are considered desirable materials for constructing delivery systems to encapsulate, protect, and release bioactive components in nutraceuticals, pharmaceuticals, and food. Therefore, this paper is approached to fabricate the carvacrol‐loaded zein/rosin (Z/R) and zein/shellac (Z/S) composite nanoparticles (NPs). Findings in the present work will help further understanding of the interaction between alcohol–soluble biopolymers (e.g., zein, rosin, and shellac) and provide new insight into the development of natural carriers for bioactive compounds.

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Recently, nanobiotechnology has a very wide range of applications, and one of them is the application of nanoparticles for delivery systems of active substances. Nanoparticles are one of the most unique entities that enhance performance, expand applications, and provide an opportunity to develop materials that can address many scientific challenges. Hollow nanoparticles-nanocapsules built from plant proteins have suitable physico-chemical and functional properties, which enable them to encapsulate hydrophilic and hydrophobic bioactive compounds. Apart from their essential function of providing amino acids for human consumption, proteins also play a prominent role in the preparation, processing, storage and consumption of food and contribute to the quality and sensory properties of food products. The development of nanoparticles with specific properties is encouraged by their application in nanotechnology, food and agricultural systems, especially the development of bioactive components of functional food, with improved solubility, physico-chemical stability, oral bioavailability and sensory characteristics. This paper provides an overview of plant proteins that can be used for the production of nanocapsules, their functional properties, as well as the methods that can be used to obtain nanocapsules based on plant proteins.