Severe fever with thrombocytopenia syndrome (SFTS) is a newly discovered emerging infectious disease that has recently become epidemic in Asia. The causative agent of SFTS is a novel phlebovirus in the family Bunyaviridae, designated SFTS virus (SFTSV). SFTS clinically presents with high fever, thrombocytopenia, leukocytopenia, gastrointestinal disorders, and multi-organ dysfunction, with a high viral load and a high case-fatality rate. In human infection, SFTSV targets microphages, replicates in the spleen of infected mice, and causes thrombocytopenia and a cytokine storm. The tick disseminates virus to humans and animals, forming a special transmission model in nature. Person-to-person transmission though direct contact with patient blood has been frequently reported. Measurements of viral RNA and antibodies have been established for diagnosis, but vaccines and specific therapeutics are not available so far.

An emerging infectious disease, severe fever with thrombocytopenia syndrome (SFTS), was identified to be associated with a novel SFTS virus (SFTSV). Transmission of the disease among humans has been described, but clinical impact factors and transmission mechanisms still need further study. An outbreak of person-to-person transmission of SFTS in a cluster of nine patients that occurred in an SFTS endemic area, Penglai County, Shandong province, China, was investigated. We found that the onset date of all eight secondary SFTS patients ranged from 7 to 13 days after exposure to the corpse of the index patient, and clinical incubation time was mostly focused on 9-10 days (n = 6). The two dead patients, including the index patient and one secondary infected patient, presented unusually high levels of viral load (6 × 10(8-9) copies/mL), low levels of platelets count (<55 × 10(9)/L), and significant increase of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and creatine kinase values in the second week, and died on day 10 or 11 after disease onset. Genetic sequencing revealed 100% homology among virus strains isolated from the index patient and five secondary patients. Risk factors assessment of the person-to-person transmission revealed that the major exposure factor was blood contact without personal protection equipment. Information from this study provided solid references of SFTS incubation time, clinical and laboratory parameters related to SFTS severity and outcome, and biosafety issues for preventing person-to-person transmission or nosocomial infection of SFTSV.

Different from conventional reconfigurable intelligent surfaces (RIS), simultaneous transmitting and reflecting RIS (STAR-RIS) can reflect and transmit signals to the receiver. In this paper, to serve more ground users and increase deployment flexibility, we investigate an unmanned aerial vehicle (UAV) equipped with STAR-RIS (STAR-RIS-UAV)-aided wireless communications for multi-user networks. Energy splitting (ES) and mode switching (MS) protocols are considered to control the reflection and transmission coefficients of STAR-RIS elements. To maximize the sum rate of the STAR-RIS-UAV-aided coordinated multipoint (CoMP) cellular system for multi-user networks, the corresponding beamforming vectors as well as transmitted and reflected coefficient matrices are optimized. Specifically, instead of adopting the alternating optimization, we design an iteration method to optimize all variables for both the ES and MS protocols at the same time. Simulation results reveal that the STAR-RIS-UAV-aided CoMP system has a much higher sum rate than systems with conventional RIS or without RIS. Furthermore, the proposed structure is more flexible than fixed STAR-RIS and could greatly promote the sum rate.