On-going pandemic pneumonia outbreak COVID-19 has raised an urgent public health issue worldwide impacting millions of people with a continuous increase in both morbidity and mortality. The causative agent of this disease is identified and named as SARS-CoV2 because of its genetic relatedness to SARS-CoV species that was responsible for the 2003 coronavirus outbreak. The immense spread of the disease in a very small period demands urgent development of therapeutic and prophylactic interventions for the treatment of SARS-CoV2 infected patients. A plethora of research is being conducted globally on this novel coronavirus strain to gain knowledge about its origin, evolutionary history, and phylogeny. This review is an effort to compare genetic similarities and diversifications among coronavirus strains, which can hint towards the susceptible antigen targets of SARS-CoV2 to come up with the potential therapeutic and prophylactic interventions for the prevention of this public threat.

: The world has been pushed to the edge of a precipice commonly been addressed to as Coronavirus S (SARSCoV2), one of the world’s most widespread viral pandemic in recent times. Many studies are underway and investigating the new role of existing drugs, exploring the safety and efficacy of recently developed vaccines,after getting detailed insights into the behavioural characteristics of SARS-CoV2. Presently supportive &symptomatic treatment along with practices like disease surveillance, contact tracing, and early diagnosis mayhelp control the future of COVID-19 outbreaks. Effort has been made to compile the information about coronavirus; its clinical manifestations, differential diagnosis, preventive aspects, and therapeutic options as a review.