Despite the prevalence of arterial hypertension among both sexes, there are data on the presence of gender diff erences in its formation and course.The purpose of the study: to identify gender characteristics in the clinical and biochemical status of patients suff ering from stage 1 and 2 of arterial hypertension.Material and methods. 80 patients of the second mature age with confi rmed arterial hypertension were examined. The patients were divided into 2 groups: the fi rst group consisted of 44 patients with stage 1 arterial hypertension (11 men and 33 women), the second group consisted of 36 patients with stage 2 disease (25 men and 11 women). All patients underwent a biochemical blood test; the glomerular fi ltration rate, the thickness of the Intima-media complex of the common carotid artery with the processing of the results by the Smirnov–Kolmogorov test were determined.Results. With the stage I arterial hypertension in both sexes, the level of blood pressure was corresponding to it. With stage II, the blood pressure in men corresponded to the level of the 1st stage, and in women to the level of the 2nd stage arterial hypertension. The level of total cholesterol and low-density lipoprotein cholesterol in all cases exceeded the normal level, prevailing in both groups in women. This was accompanied by an imbalance in the levels of thromboxane B2 and 6-ketoprostaglandin F1α at stage I hypertension, which was more pronounced in women and increased with the higher stage of the disease. The glomerular fi ltration rate in men of both groups was intact. In women, it was reduced at the onset of the disease, and kept decreasing at stage II. The width of the intima-media complex in women prevailed over this indicator in men at stage I and further increased at stage II.Conclusion. From the start of the development of arterial hypertension, women have had more pronounced and faster progressive lipid, hemostatic, renal and sclerotic changes compared to men.

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