Control of avian coccidiosis is increasingly being achieved by the administration of low doses of Eimeria oocysts to newly hatched chicks. The purpose of this study was to test the efficacy of gel beads containing a mixture of Eimeria acervulina, Eimeria maxima, and Eimeria tenella oocysts as a vaccine to protect broilers raised in contact with litter. Newly hatched chicks were either sprayed with an aqueous suspension of Eimeria oocysts or were allowed to ingest feed containing Eimeria oocysts-incorporated gel beads. Control, 1-day-old chicks were given an equivalent number of Eimeria oocysts (10(3) total) by oral gavage or received no vaccine (nonimmunized controls). All chicks were raised in floor-pen cages in direct contact with litter. At 4 wk of age, all chickens and a control nonimmunized group received a high-dose E. acervulina, E. maxima, and E. tenella challenge infection. Chickens immunized with Eimeria oocysts in gel beads or by spray vaccination displayed significantly (P < 0.05) greater weight gain (WG) compared to nonimmunized controls. Feed conversion ratio (FCR) also showed a significant (P < 0.05) improvement in both groups relative to nonimmunized controls. Moreover, WG and FCR in both groups was not significantly different (P > 0.05) from chickens immunized by oral gavage or from nonimmunized, noninfected controls. Oocyst excretion after Eimeria challenge by all immunized groups was about 10-fold less than in nonimmunized controls. These findings indicate that immunization efficacy of gel beads and spray vaccination is improved by raising immunized chicks in contact with litter.
The first oil-well casing-perforating job was performed in 1932 by the Lane-Wells Company. who pioneered the bullet-gun perforating technique. With the steadily increasing demand for oil and gas over the last decades, operators have been forced to explore deeper, hotter reservoirs to find the most prolific reservoirs. These deep, high-pressure opportunities have required constant changes to equipment and services to increase their technical capabilities so that they can perform effectively in the more critical environments to which they are subjected. These environments include the ever-increasing high-pressure and high-temperature reservoirs into which exploration has been venturing. Perforating has been continuing to require higher-shot densities, propellants, and larger perforating guns to meet these new challenges. A major problem with these environmental increases, however, has concerned the difficulty to predict dynamic wellbore behaviors that would cause tubulars to collapse and bend and packers to unset as perforating guns were detonated. Research to understand pressure behavior during the perforation event in addition to the solid loading that is imparted to the tubulars, packers, and other completion hardware in the perforating bottomhole assembly was needed, if the industry was to go forward with a high level of confidence that wells could be completed safely and cost effectively. This paper discusses a shock-wave modeling computer-software program that evaluates the mechanical risk factors of well components to ensure that the health, safety, environment, and service-quality needs of a design are covered and that the proposed equipment configurations will maintain mechanical integrity. A time-marching, finite-differences technique is applied as the numerical method for both fluids and solids. The software is installed on a personal computer, and typically, executes the models in several minutes to several hours, depending on job-design complexity. The physics-based model has been validated with special high-speed recorders that sense pressure, temperature and acceleration at a sampling frequency of 115,000 samples per second. Data from two oil and gas wells offshore Brazil will be used to demonstrate the success of the operating configurations generated from use of this program. Introduction It is a fact that perforating-gun detonation creates dynamic loading on tubulars, packers, casing and other completion equipment, and the importance of having the capability to predict dynamic wellbore behaviors through modeling continues to increase in importance (Garcia et al., 2009) (Weaver et al, 2009). Relying on old " rules of thumb?? or using standard mechanical configurations with shock absorbers to cover all perforating cases can lead to catastrophic results. A major service and engineering company has developed a software program that accurately simulates the dynamic and loading forces created during perforating. This tool provides the capability to plan and design the well completion accordingly. The software modeling service determines the dynamic pressure behavior during the perforation event in addition to the solid loading that is imparted to the tubulars, packers, and other completion hardware in the bottomhole assembly (BHA). The physics-based numerical model accounts for fluid dynamics and dynamic failure of solids by accounting for pressures on the surface, drag, internal stress waves and reflections, and gravity. The time-marching finite difference technique is applied as the numerical method for both fluids and solids, and basically, simulates downhole performance of proposed string configurations in the particular environment to which it will be subjected. The software is compiled on a personal computer, and typically, executes in periods of several minutes to several hours, depending on the complexity of the job design. The numerical solution accounts for failure modes such as:
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.