The injection of Juvederm Ultra Plus gel is a relatively safe procedure that allows for short-term improvements in objective and subjective outcome measures of vocal function in patients with glottic insufficiency, provided the surgeon remains alert to the possibility of postprocedural injection site inflammation.
The proteomic approach allows detection of significant differences in protein abundance in CRSwNP and provides unique insight into the pathophysiology of this common disease.
Objective: Vocal cord nodules are of the most common benign laryngeal pathologies that may cause dysphonia and hoarseness. This study aimed to assess the effectiveness of surgical versus nonsurgical interventions for vocal cord nodules.Method: In a cohort study, 60 patients with vocal cord nodules were enrolled in 2 groups. The study was carried out from 2010-2011 at Imam Reza Hospital of Tabriz. One group underwent surgical microscopic excision, and the other one was managed with medical and speech therapies. The results were evaluated 3 months later.
Results:The mean age of patients was 37.35 ± 9.22 years with male to female ratio of 36/24. In each group, 27% of patients were smokers. Sixty percent of patients in the surgical group had job-related use of voice, compared to 72% in the nonsurgical group. In the surgical group, 63% of patients had bilateral nodules versus 76% in the nonsurgical group. In evaluating improvement of voice quality there was no statistically significant difference between the 2 groups regarding patient satisfaction and the surgeon's evaluations (P = .16 and P = .07, respectively).
Conclusion:There was no definite difference between surgical and nonsurgical interventions of vocal cord nodules.
Laryngology/Broncho-EsophagologyOffice-Based injection laryngoplasty with Hyaluronic Acid Gel David Upton, MD (presenter); Matthew Johnson, MD; Sherri Zelazny; Seth H. Dailey, MD Objective: Many injectables are available for vocal fold augmentation, but the role of Juvederm Ultra Plus hyaluronic acid gel has not been well examined. This study was conducted to assess the safety and clinical effectiveness of office-based injection laryngoplasty of Juvederm Ultra Plus gel in patients with glottic insufficiency (GI).Method: Prospective case series of 27 patients with GI treated with unsedated office-based injection laryngoplasty of Juvederm Ultra Plus gel over a 20 month period. Preinjection acoustic and aerodynamic measures, Voice Handicap Index, Glottal Function Index, and Dysphonia Severity Index were compared with values recorded at 1 and 4 months postinjection.Results: Data for 26 patients were available for follow-up analysis at 1 month, and 12 patients' data were available at 4 months. Etiologies of GI included presbylaryngis (n = 11), unilateral vocal fold paralysis (n = 10), scar (n = 2), and others (n = 5). Eighty-nine percent underwent transoral injection, and 11% received transcervical injections. Significant improvements compared to preinjection levels (P < .03) were shown in all outcome measures at 1 and 4 months, respectively. Although there were no procedural complications, 1 patient required intravenous steroid therapy for temporary glottic inflammation that resolved without permanent sequelae.
Conclusion:The injection of Juvederm Ultra Plus gel is a safe procedure that allows for reliable improvements in objective and subjective outcome measures of vocal function in patients with GI provided the surgeon remains alert for the possibility of postprocedural injection site inflammation....
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