Purpose-Geographic atrophy (GA) may cause significant compromise of visual function, even when there still is good visual acuity (VA), because of parafoveal scotomas and foveal function abnormalities antedating visible atrophy. This study evaluates the visual function abnormalities at baseline and the 2-year worsening of VA and reading rate for eyes with GA compared with a group of eyes with drusen only.Methods-Seventy-four eyes with GA and VA greater than or equal to 20/50 from a prospective natural history study of GA were included, as were 13 eyes with only drusen. Baseline visual function testing and 2-year VA and maximum reading rate are reported.Results-The worsening of VA in decreased luminance and foveal dark-adapted sensitivity showed severe abnormalities for the GA group. Contrast sensitivity was significantly reduced for the eyes with GA. Half the eyes with GA, but none of the drusen eyes, had maximum reading rates below 100 words per minute. A scanning laser ophthalmoscope (SLO) measure of the scotoma near fixation combined with a measure of residual foveal function accounted for 54% of the variability in maximum reading rate in the eyes with GA.Of 40 eyes with GA observed for 2 years, half lost greater than or equal to 3 lines of VA and one quarter lost greater than or equal to 6 lines. The nine eyes with drusen with follow-up had no significant change in VA. Low foveal dark-adapted sensitivity, SLO measures of the scotoma within 1° of fixation, and low maximum reading rate were statistically significant risk factors for doubling of the visual angle. Significant reduction in maximum reading rates at 2 years was present for the eyes with GA.Conclusions-The eyes with GA with good VA have profound decreases in visual function, particularly in dim lighting and in reading. Half the eyes with GA had doubling in visual angle at 2 years after the baseline examination, whereas the drusen eyes remained essentially unchanged. Impaired visual function at baseline was predictive of an adverse outcome for the eyes with GA.Address correspondence to Janet S. Sunness, MD, 550 N. Broadway, 6th Floor, Baltimore, MD 21205. The baseline visual function abnormalities were presented at the 1995 meeting of the Association for Research in Vision and Ophthalmology, Fort Lauderdale, Florida. The natural history aspect of this article is being submitted as an abstract for presentation at the 1997 American Academy of Ophthalmology Meeting, San Francisco, California.The authors have no proprietary interest in the development or marketing of instruments used in this study or in competing instruments. NIH Public Access Author ManuscriptOphthalmology. Author manuscript; available in PMC 2009 August 23. Published in final edited form as:Ophthalmology. 1997 October ; 104(10): 1677-1691. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author ManuscriptGeographic atrophy (GA) of the retinal pigment epithelium (RPE) is a form of advanced agerelated macular degeneration (AMD) that can cause central visual loss. It differs...

There is a preference for fixation with the scotoma to the right in eyes with GA. Patients with Stargardt disease use different strategies for fixation, perhaps due to subclinical pathology adjacent to the atrophic regions. The size of the atrophic area in GA plays the predominant role in reading rate for eyes that have already lost foveal vision.

Abstract. The histopathologic features of three keratoplasty specimens from three cases involving square graft procedures performed by Dr. Castroviejo are reported. Light and electron microscopy were performed. In two of the cases, repeat keratoplasties were performed because of recurrent corneal dystrophies. In the third case, a repeat keratoplasty was performed because of graft failure. [Ophthalmic Surg Lasers 1996;27:127-132.]