Abstract:Purpose: To review the current literature on the various extended-release methylphenidate stimulant preparations regarding safety and efficacy in children and adolescents with attentiondeficit/hyperactivity disorder (ADHD). Conclusions: Extended-release methylphenidate is effective in treating the symptoms of ADHD in children and adolescents. The different available dosage forms gives the clinician the opportunity to individualize treatment based on patient needs. * Data Sources: The literature included was retrieved from PubMed/MEDLINE using the terms methylphenidate, stimulant, extended-release, children, and attention/hyperactivity disorder. Reference citations from publications identified were also reviewed. SummaryStudy Selection and Data Extraction: Double-blind clinical trials found using the search strategy above were included in this review. Open-label studies were included if no double-blind trials were published for that methylphenidate preparation.

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