Preoperative stress, anxiety and lack of cooperative ability of paediatric patients need sedation for radiological procedure. Aims: The purpose of study is to compare and evaluate efficiency and safety of two doses of intranasal midazolam. Settings and Design: This is a prospective Randomized controlled study of interventional type of study. Methods and Material: Sixty patient of age 1 to 4 years, ASA 1 and ASA2 undergoing radiological procedure were randomly divided into two groups. Group A received 0.3 mg/kg and Group B received 0.5 mg/kg of intranasal spray of midazolam. Sedation score, haemodynamic variations, ease of separation, Venepunture response and side effect were studied. Statistical analysis used: Data analysis was performed using SPSS for Windows, version 20.0(SPSS Inc., Chicago, IL) Results: Higher sedation score achieved earlier with 0.5mg/kg dose, Parenteral separation and IV line insertion was more easier with 0.5 mg/kg dose but recovery slight delay compare to 0.3 mg/kg dose after 20 min of procedure completion but there was no much prolongation of recovery time, at 30 min of all patient discharged in both groups. Conclusions: High Sedation score, parentral separation and response to IV line was earlier and easier with 0.5 mg/kg dose. Key Messages: Intranasal Midazolam is safe and effective as sedative in paediatric radiological procedure.

Background: We hypothesized that the effectiveness of dexmedetomidine versus labetalol in attenuation of hemodynamic stress responses of laryngoscopy and intubation and effect of dexmedetomidine in post-operative sedation .Also we studied adverse effect of both the drugs. Method: Following approval by institutional ethics committee and 60 patients, who posted for elective surgeries under general anaesthesia taken. Study drug was given in 100 ml of saline over 10 mins. Inj dexmedetomine 1 microgram/ kg and Inj. labetalol 0.25 mg/kg given and parameters like HR, SBP, DBP, Spo2, and sedation score were monitored immediately and after 3,5 and 10 minutes. Result: There was a reduction in the heart rate and mean arterial pressure response to intubation in both Dexmedetomidine and labetalol but there was statistically significant reduction of heart rate and arterial pressure response to intubation in Dexmedetomidine group. There was statistically significant sedation in Dexmedetomidine group. Conclusion: Dexmedetomidine 1μ/Kg given slowly over 10 minutes intravenously 5 minutes prior to induction, attenuates the cardiovascular responses to laryngoscopy and intubation in a better manner than Labetalol 0.25mg/Kg.