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The VDR BsmI polymorphism may have a protective role against the development of osteoporosis.

Using the forced-oscillation method, we measure the dispersion of Young's modulus, extensional attenuation, and Poisson's ratio of tight sandstone and carbonate samples at seismic frequencies (1-1000 Hz) under a constant confining pressure of 20 MPa and for a water saturation varying between 0% and 100%. The experimental data suggest that the dispersion of Young's modulus and attenuation of tight rocks is significant in a broad frequency band spanning over 1-1000 Hz. A comparison with the high-porosity and high-permeability sample data shows a contrasting dispersion and attenuation characteristics. For the tight sandstone, Young's modulus reaches a maximum dispersion of 16% at 60% water saturation and a 13% dispersion at 100% saturation. Attenuation is insignificant in dry condition and for water saturation ≤30%. In contrast with the peak attenuation occurring at very high water saturation (e.g., 80-100%) in partially saturated high-porosity rocks, peak attenuation of tight sandstone takes place at a water saturation of 60%. For the tight carbonate, the magnitude of dispersion (~3%) and attenuation are markedly lower for all saturation levels. In the explored frequency range (1-1000 Hz), Young's modulus increases monotonously, and no obvious attenuation peak is observed when saturation levels are greater than 10%. Using well-established theoretical models based on physical properties and microstructure of the tested rocks, we suggest that the observed attenuation characteristics are possibly attributed to the combined physical mechanism of microscopic (squirt) flow, mesoscopic flow in partially saturated rock, and shear dispersion due to viscous flow in grain contacts. Key Points:• Dispersion and attenuation of both tight sandstone and carbonate are distributed across frequency range of 1-1000 Hz • Extensional attenuation in tight sandstone is saturation dependent with a maximum at 60% saturation, which contrasts with that of porous sandstones • The coupled pore fabric and fluid distribution heterogeneity in tight rocks might cause complex dispersion and attenuation characteristics

This work aimed to compare the stress distribution and mechanical properties of our bridge combined fixation system and commonly used metal locking plate screw system by finite element analysis and by using the Zwick/Z100 testing machine. In addition, we also investigated the clinical outcome of our bridge combined fixation system for femoral fractures in 59 patients from June 2005 to January 2013. As a result, the stress distribution in the bone plate and screws of metal locking plate screw system during walking and climbing stairs was significantly lower than that of metal locking plate screw system. No significant difference in the displacement was observed between two systems. The equivalent bending stiffness of bridge combined fixation system was significantly lower than that of metal locking plate screw system. There were no significant differences in the bending strength, yield load, and maximum force between two systems. All the cases were followed up for 12-24 months (average 18 months). The X-ray showed bone callus was formed in most patients after 3 months, and the fracture line was faint and disappeared at 6-9 months postoperatively. No serious complications, such as implant breakage and wound infection, occurred postoperatively. According to self-developed standard for bone healing, clinical outcomes were rated as excellent or good in 55 out of 59 patients (success rate: 93.2%). Therefore, our findings suggest that our bridge combined fixation system may be a promising approach for treatment of long-bone fractures.

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