Background: Enhancing competencies of patient safety and quality of care is an actual and important issue in Bachelor of Nursing education. In 2010, the Dutch ministry of health adopted ten themes of patient safety and developed six competences for patient safe nursing care. Nursing schools integrated these competences in their Bachelor of nursing programs. This study evaluates the progress of undergraduate nursing students on the six competences, before and after a course on the management of innovation and policy-making of safety management.