Carbon−carbon bond cleavage of biphenylene was
achieved with
(C5Me5)M(C2H4)2
(M =
Rh, Co) to give the bimetallic species
(C5Me5)2M2(2,2‘-biphenyl).
The isomorphous solid state
X-ray structures of these complexes showed the biphenyl substrate to be
σ-coordinated to
one metal and η4-bound to the other. These complexes
display dynamic behavior,
interchanging the σ- and π-bonding. Variable-temperature NMR
studies were performed
on both binuclear species, and the energy barrier for interconversion
of the two (C5Me5)
fragments was calculated to be ΔG
⧧ (350 K)
= 16.8 kcal/mol and ΔG
⧧ (248 K) = 11.4
kcal/mol for the rhodium and cobalt complexes, respectively.
(C5Me5)2Rh2(2,2‘-biphenyl)
reacted
with CO to give (C5Me5)Rh(CO)2
and (C5Me5)Rh(CO)(2,2‘-biphenyl), while
the cobalt analog
gave (C5Me5)Co(CO)2 and
fluorenone.
(C5Me5)2Co2(2,2‘-biphenyl)
gave
(C5Me5)Co(PMe3)2
and
(C5Me5)Co(PMe3)(2,2‘-biphenyl)
when reacted with PMe3, as determined by X-ray
crystallography of the latter complex. Both complexes were found to be
resistant to hydrogenation.
Polymeric Quaternary Ammonium Compounds (polyQACs) comprise a broad class of materials with applications in medical implants, food processing, and surface sanitizing, amongst many others. These polymeric substances are especially promising due to their potent antibacterial activity and limited hemolytic toxicity. In particular, many polyQACs have superior therapeutic indices and a lower likelihood of developing antibacterial resistance in comparison to their monomers, making them ideal materials for wound dressings, catheters, and other biomedical applications. This review outlines the history and development, previous successes, current state of the research, and future directions of polyQACs in society.
The phytotoxin diplopyrone
is considered to be the main phytotoxin
in a fungus that is responsible for cork oak decline. A carbohydrate-based
synthesis of the enantiomer of the structure proposed for diplopyrone
has been developed from a commercially available derivative of d-galactose. Key steps in the synthesis are a highly stereoselective
pyranose chain-extension based on methyltitanium, preparation of a
vinyl glycoside via Isobe C-alkynylation-rearrangement/reduction,
and RCM-based pyranopyran construction. Crystallographic and NMR analysis
confirms an earlier report that the structure originally proposed
for diplopyrone may require revision. Structural analogues were prepared
for biological evaluation, the most promising being a pyranopyran
nitrile synthesized from tri-O-acetyl-d-galactal
by Ferrier cyanoglycosidation, Wittig chain extension, and lactonization.
Biological assays revealed potent antibacterial activity for the nitrile
analogue against common bacterial pathogens Edwardsiella ictaluri and Flavobacterium columnare that cause enteric
septicemia (ESC) and columnaris disease, respectively, in catfish.
The IC50 value of 0.002 against E. ictaluri indicates
approximately 100 times greater potency than the antibiotic florfenicol
used commercially for this disease. Phytotoxic activity for all three
target compounds against duckweed was also observed. The antibiotic
and phytotoxic activities of the new pyranopyrans synthesized in this
study demonstrate the potential of such compounds as antibiotics and
herbicides.
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