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IntroductionDiabetic polyneuropathy (DPN) is a common chronic complication of type 2 diabetes. The pathogenesis of DPN is still debated, but proinflammatory cytokine mediators like interleukin-6 (IL-6) are possibly involved. We conducted this cross-sectional observational study to assess whether IL-6 levels increase in patients with DPN.

Since this is a vital developmental phase, studying the health patterns of young adults, particularly cardiovascular health, is critical. Autonomic function testing (AFT) is a crucial non-invasive procedure for determining the state of one's cardiovascular system. There are only a few studies on autonomic responsiveness in young people. To study the autonomic responses to various cardiovascular autonomic function tests among young adult subjects and to look into the gender-based variations.Males made up 114 (50.67 percent) of the total 225 individuals, while females made up the rest. The study's target age group was 18-29 years old. The CANWIN analyser of genesis medical systems was used to investigate autonomic function tests such as resting heart rate, heart rate reaction to slow deep breathing (SDB), Valsalva Ratio (VR), 30:15 ratios response to standing, and blood pressure response to sustained handgrip. CANWIN is a state-of-the-art Cardiac Autonomic Neuropathy (CAN) Analysis System with interpretation for PC Windows*. The data was analysed statistically using STATA software (version 13.1).: Dysautonomia was seen in 150 of the 225 participants (66.66 percent). The number of dysautonomia participants was not statistically different between males and females (P value=0.15).: Anxiety, stress, a poor diet, and a disrupted sleep cycle could all contribute to the high number of dysautonomia patients. There have been a number of reports linking dysautonomia to nutritional deficits. To investigate the causative factors, more longitudinal studies including nutritional status assessments are needed.

Diabetic poly neuropathy (DPN) is the most common chronic complication of type 2 diabetes. Aim of this observational cross sectional study is to establish correlation between level of TNF α and severity of DPN if any. The forty seven subjects were divided into three groups. Group1:15 healthy normal controls; Group2:12 T2DM patients without neuropathy controls; Group3:20 T2DM patients with painful neuropathy case. To measure TNF-α 5ml blood was drawn and centrifuged and then TNF-α measurement was done with Ray Bio Human TNF-α ELISA kit. Plasma TNF-α shows high correlation with progress of neuropathy; In early phases of diabetes (group2) TNF-α shows a tendency to rise, which increases further with development of overt painful neuropathy (group3).