This paper considers the kinetic pathways of hydrogen oxidation in turbulent, premixed H 2-air flames. It assesses the relative roles of different reaction steps in H 2 oxidation relative to laminar flames, and the degree to which turbulence-chemistry interactions alters the well understood oxidation pathway that exist in laminar flames. This is done by analyzing the turbulent, lean (φ = 0.4), H 2-air flame DNS database from Aspden et al. [17]. The relative roles of dominant reaction steps in heat release and radical formation/consumption are analyzed at different Karlovitz numbers and compared with laminar stretched flame calculations from counterflow flames and perfectly stirred reactors. It is found that both the progress variable conditioned and spatially integrated contributions of the dominant reactions remain qualitatively similar between a highly turbulent and a laminar unstretched flame. Larger changes, up to a factor of about two, occur in the relative roles of reactions with secondary influences on heat release and radical production/consumption. These results suggest that the kinetic routes through which H 2 is oxidized remain essentially constant between laminar, unstretched flames and high Karlovitz number flames.
Improved understanding of turbulent flames characterized bynegative consumption speed-based Markstein lengths is necessary to develop better models for turbulent lean combustion of high hydrogen content fuels. In this paper we investigatethe topology and burning rates of turbulent, lean( = 0.31), H 2 /air flames obtained from a recently published DNS database [1]. We calculate local flame front curvatures, strain rates, thicknesses, and burning velocities and compare these values to reference quantities obtained from stretched laminar flames computed numerically in three modelgeometrical configurations-a counterflow twin flame, a tubular counterflow flame and an expanding cylindrical flame.We compare and contrast the DNS with these model laminar flame calculations, and show both where they closely correlate with each other, as well as where they do not. These results in the latter case are shown to result from non-flamelet behaviors, unsteady effects, and curvature-strain correlations. These insights are derived from comparisons conditionedon differenttopological features, such as portions of the flame front with a spherical/cylindrical shape, the leading edge of the flame, and portions of the flame front with low mean curvature.We also show that reference time scales vary appreciably over the flame, and characterizing the relative values of fluid mechanic and kinetic time scales by a single value leads to erroneous conclusions. For example, there is a two order of magnitude decrease in chemical time scales at the leading edge of the front relative to its unstretched value. For this reason, the leading edge of the front quite closely tracks quasi-steady calculations, even in the lowest Damkohler number case, Da F~0 .005.
This paper considers the kinetic pathways of hydrogen oxidation in turbulent, premixed H 2-air flames. It assesses the relative roles of different reaction steps in H 2 oxidation relative to laminar flames, and the degree to which turbulence-chemistry interactions alters the well understood oxidation pathway that exist in laminar flames. This is done by analyzing the turbulent, lean (φ = 0.4), H 2-air flame DNS database from Aspden et al. [17]. The relative roles of dominant reaction steps in heat release and radical formation/consumption are analyzed at different Karlovitz numbers and compared with laminar stretched flame calculations from counterflow flames and perfectly stirred reactors. It is found that both the progress variable conditioned and spatially integrated contributions of the dominant reactions remain qualitatively similar between a highly turbulent and a laminar unstretched flame. Larger changes, up to a factor of about two, occur in the relative roles of reactions with secondary influences on heat release and radical production/consumption. These results suggest that the kinetic routes through which H 2 is oxidized remain essentially constant between laminar, unstretched flames and high Karlovitz number flames.
Ubiquitously expressed in mammalian cells, the Kelch-like ECH-associated protein 1 (Keap1)–NF erythroid 2–related factor 2 (Nrf2) complex forms the evolutionarily conserved antioxidation system to tackle oxidative stress caused by reactive oxygen species. Reactive oxygen species, generated as byproducts of cellular metabolism, were identified as essential second messengers for T cell signaling, activation, and effector responses. Apart from its traditional role as an antioxidant, a growing body of evidence indicates that Nrf2, tightly regulated by Keap1, modulates immune responses and regulates cellular metabolism. Newer functions of Keap1 and Nrf2 in immune cell activation and function, as well as their role in inflammatory diseases such as sepsis, inflammatory bowel disease, and multiple sclerosis, are emerging. In this review, we highlight recent findings about the influence of Keap1 and Nrf2 in the development and effector functions of adaptive immune cells, that is, T cells and B cells, and discuss the knowledge gaps in our understanding. We also summarize the research potential and targetability of Nrf2 for treating immune pathologies.
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